Trazodone use. Trazodone - instructions, use, indications, contraindications, action, side effects, analogues, composition, dosage

Prohibited at breastfeeding

Forbidden for children

Has restrictions for the elderly

Has limitations for liver problems

Has limitations for kidney problems

Antidepressants are prescribed for various mental disorders to relieve negative symptoms. Trazodone is especially popular among such drugs, which, according to the instructions for use, is most effective in depressive states that have arisen as a result of exposure to external or internal factors.

The active substance of the drug trazodone is a thiazolopyridine derivative. It has a special chemical structure, therefore it does not belong to any group of antidepressants (tri- or tetracyclic). Trazodone itself is a chemical found in many medications. In Russia, the full analogue of the foreign drug Trazodone - Trittiko pilyule_nervi-521 (Italy) and Azona (Finland) is especially common.

Drugs with trazodone belong to a large group of drugs - antidepressants. Such funds are intended for the treatment of mental disorders - depressions of various origins.

The international non-proprietary name is determined by the content of the active ingredient in the drug, which has one or another effect on the body. In this case, the INN is trazodone (Trazodone). The scope of the medicinal substance is psychiatry. Trazodone-based drugs are used to treat depressive disorders in adults and the elderly.

Description of the drug

Release forms, cost

Trazodone hydrochloride is a white crystalline powder. It is odorless and dissolves well in water. On its basis, tablets, capsules or injections are produced. Such pharmacological forms have their own characteristics:

1. Tablets with a slow release of the active substance. They are oblong in shape and white-yellow in color. Packed in aluminum blisters of 10 pieces. The carton box contains 20 or 30 tablets.
2. Capsules for oral administration. Packed in plastic blisters of 10 pieces. The cardboard box contains 30 or 100 capsules.
3. Injection. It is a colorless or yellowish odorless transparent liquid. It is contained in glass ampoules with a volume of 5 ml (in 1 ampoule 50 mg of trazodone).

On the this moment Trazodone is not available in Russian pharmacies, and the cost of drugs with trazodone under the trade name Trittiko is presented below.

Composite Components

The composition of the drug is somewhat different depending on the dosage form:

• a regular-acting capsule may contain 25, 50, or 100 mg of trazodone;
• 5 ml of solution for intravenous or intramuscular administration contains 50 mg of the active substance, as well as additionally water for injection;
• 1 tablet of prolonged action contains 75 or 150 mg of trazodone and auxiliary components - carnauba wax, sucrose, magnesium stearate and povidone.

Pharmacodynamics and pharmacokinetics

The mechanism of action of trazodone is not fully understood. Studies show that this substance is able to selectively inhibit the reuptake of serotonin by specific receptors in the brain. It is also an alpha1-adrenergic receptor antagonist. At the same time, trazodone does not inhibit MAO and has no effect on the stimulation of the central NS.

Mechanism of action of antidepressants

In addition to antipsychotic (eliminating manifestations of depression, fear), it has a slight sedative and hypnotic effect, improves the quality of sleep. It also tends to eliminate the somatic manifestations of anxiety:

• cardiopalmus;
• increased sweating;
• frequent urination;
• pain in the head and muscles.

Pharmacokinetic features of trazodone:

• rapidly absorbed from the digestive organs;
• the rate of absorption decreases when the substance is taken with or immediately after food;
• the highest concentration is observed half an hour after ingestion (when taken with food - after 2 hours);
• high connection with blood proteins (more than 90%);
• able to penetrate the blood-brain and placental barriers;
• the metabolic process occurs in the liver with the release of the active metabolite m-chlorophenylpiperazine;
• excreted mainly by the kidneys (about 75%) and together with bile (20%);
• the half-life takes 2 phases: the early one lasts up to 6 hours, the late one - from 5 to 9 hours;
• complete elimination from the body occurs 98 hours after application.

Indications and contraindications for taking Trazodone

As a rule, the main indications for prescribing the drug are depressive states of various origins (neurotic, somatic, psychotic, depression due to external factors). They are often accompanied by emotional and physical tension, feelings of fear and anxiety.

Trazodone may also be used to treat the following conditions:

• individual intolerance to the active substance;
• severe violations of the functioning of the liver or kidneys;
• priapism in men (prolonged painful erection that is not associated with arousal);
• period of acute infarction;
• violation of the heart rhythm;
• severe poisoning from alcohol or certain drugs (for example, sleeping pills).

It is not recommended to use the drug for the treatment of children and adolescents until they reach the age of majority. They are much more likely than adults to develop suicidal tendencies while taking antidepressants.

During pregnancy, trazodone can be used, since clinical trials have not shown any negative effects on the fetus, its growth and development. Therapy is carried out with caution and only if the expected benefit to the mother is higher than the possible risk to the fetus. If a pregnant woman takes medication immediately before childbirth, then the newborn should be monitored in order to diagnose withdrawal syndrome in time.

Trazodone passes into breast milk in very small amounts. It is not known for certain how much this substance affects the child, so breastfeeding should be stopped while taking it.

Instructions for use of the drug Trazodone

The method of application and dosage regimen of the drug depends on the form of its release:

Maximum per day you can take no more than 600 mg of trazodone. The duration of therapy and dosage is determined by the attending physician individually for each patient.

Side effects

The drug can provoke various side effects. Often, when using it, thoughts of suicide arise (as with other antidepressants). Reactions that are characteristic of depression are also possible. Among side effects allocate:

Overdose

With a sharp discontinuation of the drug, a withdrawal syndrome may develop. As a rule, overdose symptoms appear on the first day after taking too high a dose. It can be:

• bouts of nausea and vomiting;
• dizziness;
• drowsiness;
• increased heart rate;
• lowering blood pressure;
• convulsions;
• violation of respiratory activity;
• coma.

Treatment of overdose is aimed at stopping the poisoning effect of trazodone. To do this, the patient's stomach is washed and sorbents are given (such actions are effective for 1 hour after poisoning). Next, symptomatic therapy is prescribed. At the same time, it is important to control the vital functions of the body (activity of the cardiovascular system, respiratory activity).

Analogues of the drug Trazodone

You can find many antidepressants on drugstore shelves. The most popular analogues of Trazodone:

Any antidepressant is prescribed only by the attending physician. Before prescribing a medicine, he takes into account the characteristics of the patient, his general condition and the severity of the symptoms.

It's no secret that the state of erection, the degree of libido, the general sexual capabilities of a man directly depend on his psychological state. It is experiences, stress, depression that lead not only to erectile dysfunction, but also to the complete suppression of normal sexuality. Therefore, it is imperative to begin treatment precisely with the stabilization of the neuropsychic state of the stronger sex, as well as with the fight against depression. Trazodone successfully fights these kinds of problems, which we will discuss below.

Instructions for use of Trazodone indicate that the drug belongs to the group of antidepressants that do not have an effect on MAO, that is, it does not stimulate the central nervous system (central nervous system). The mechanism of therapeutic action is still being studied to the end, however, antidepressant efficacy has been proven. The action of the drug is due to the fact that it selectively prevents the reuptake of serotonin by special synaptosomes of the brain. Trazodone is able to eliminate two groups of negative manifestations:

1. Somatic, manifested by palpitations, increased sweating, headache, muscle pain (myalgia), frequent urination.
2. Mental, a vivid example of which can be all sorts of fears, insomnia, a feeling of tension.

Studies have shown that Trazodone is metabolized in the liver and completely eliminated from the body after 98 hours. The drug is well absorbed from gastrointestinal tract.

In the pharmacy network, you can also find Trazodone analogues. The following are the most popular:

1. Trittiko.
2. Azona.

The active substance and dosage in all medicines are the same, so the indications, contraindications and method of use for the original will not differ from those that have analogues.

Usage details

Indications for the use of Trazodone are not limited to disorders of the sexual sphere in men. The instruction indicates the following diseases for which therapy with this drug is possible:

• Decreased libido against the background of a depressive state.
• Erectile dysfunction due to depression and other psychological problems.
• Various forms of depression (involutional, psychogenic, alcoholic).
• Depressive manifestations in organic diseases of the central nervous system, that is, in Alzheimer's disease, dementia, atherosclerosis of cerebral vessels.

In any case, the final indications are determined by the doctor, therefore, before using Trazodone, consultation with a specialist is required. In some cases, men tend not to take depression, depression seriously, attributing impotence to anything but the deplorable state of their own nervous system. Therefore, self-medication is strictly prohibited. The specialist will determine true reason erectile dysfunction, which means he will prescribe the right treatment.

Unfortunately, not everyone can prescribe Trazodone and analogues. The instructions contain the following contraindications for use:

1. Pathology of the heart and blood vessels: recent myocardial infarction, rhythm and conduction disturbances (atrioventricular blockade, ventricular arrhythmias). Patients with arterial hypertension may need to change the selected dosages of antihypertensive drugs.
2. Gastrointestinal diseases: liver failure.
3. Kidney disease, accompanied by a violation of the normal function of the kidneys and renal failure.
4. Priapism. If a man has previously had an episode of a prolonged, painful erection that required medical intervention, Trazodone is categorically contraindicated.
5. Age limit: under 18 years of age and in childhood, you can not prescribe the medicine.

Trazodone and its analogues can be prescribed to women to treat depression, but only if the lady is not pregnant and not breastfeeding. The full range of contraindications can be found in the instructions for Trazodone. Also, you can not use the drug for people who are hypersensitive or allergic to any component of the drug. Reviews of doctors confirm that the potential harm to health in such cases significantly exceeds the expected benefits.

During clinical trials, the adverse effects that trazodone hydrochloride has on the body have been identified:

• CNS and sense organs. Patients may complain of general weakness and fatigue, sleep disturbance, dizziness. More rare side effects were hallucinations, trembling of the limbs (tremor), impaired sensitivity, convulsions, etc.
• Heart and blood vessels. Observed arterial hypotension, arrhythmias.
• From the side of hematopoiesis. Perhaps a decrease or increase in leukocytes, neutropenia, rarely - hemolytic anemia.
• Gastrointestinal tract. Increased appetite, a feeling of unpleasant aftertaste in the mouth, hypersalivation (increased salivation), dyspepsia, bloating, bile stasis. In some cases, an increase in liver parameters (bilirubin, amylase), jaundice was observed.
• Urogenital system. Priapism, urinary disorders.
• The immune system. Like all medicines, Trazodone can cause allergies.

More rare extrasystemic manifestations were alopecia (alopecia), skin diseases (psoriasis), chest pain without an appropriate diagnosis. Symptoms of an overdose resemble those of side effects, but are more clinically pronounced. For treatment, symptomatic therapy is used, since there are no specific antidotes.

special instructions

Given the characteristics of metabolism and the effects of the drug on the body, together with some other drugs, Trazodone should be administered with caution.

• Ritonavir. In clinical trials in healthy patients, it was noted that Ritonavir slows down the half-life of Trazodone and increases the risk of side effects: nausea, syncope, hypotension.
• Other inhibitors of CYP3A4 (fluoxetine, ketoconazole). They act like Ritonavir, which belongs to the same group.
• Carbomazepine. Reduces the concentration of the drug in the blood, and therefore, Trazodone may not have the desired effect.
• Warfarin. Currently, studies are underway on their combined use. There are already facts that both drugs mutually affect the concentration of active components in the blood serum, which is confirmed by the reviews of scientists published on specialized sites.
• Antihypertensive drugs. Caution should be exercised when used together, as the risk of hypotension increases.

Reviews of researchers indicate that during treatment with Trazodone, it is necessary to monitor general blood counts (leukocytes, blood count), determine the level of liver enzymes, and do an ECG (electrocardiogram). During treatment, it is advisable to refrain from driving vehicles and working with precise mechanisms.

Method of use

The method of application may vary slightly in men of different groups. In some situations, single and daily doses should be slightly adjusted:

A tablet of the original drug or analogue is taken before meals or 3-4 hours after, since simultaneous use with food slows down the absorption of Trazodone. In the event that combined therapy for erectile dysfunction is prescribed, the dose of Trazodone is reduced to 50 mg / day.

Where to follow him

It is better to purchase the remedy in a pharmacy, which is confirmed by the reviews of doctors. The price of a medicine and its analogues may fluctuate in different regions:

When buying from online pharmacies, the price may include postage or courier fees. Check this information.

Be aware that Trazodone is a serious drug, which is undesirable to take without medical prescription. Therefore, no matter how much you want to quickly get rid of erectile dysfunction on the background of depression, you should not prescribe this medicine yourself.

Ivan, 32 years old:

Against the backdrop of depression, sexual desire disappeared. After a month of using Tradozon positive effect appeared to be good. I will definitely continue the treatment prescribed by the doctor.

Valery Sergeevich, 47 years old:

The erection disappeared along with any desire to have sex after severe stress, against the backdrop of depression that followed. I started taking Tradozon after consulting a doctor and have no regrets. Firstly, it really got better after a while sex life Secondly, the depression receded. Now I look at things positively.

Sergey Leonidovich, psychotherapist:

Indeed, Trazodone and its analogues are able to successfully deal with erectile dysfunction in men suffering from depression. The drug has long been adopted by the specialists of the clinic where I work. The main thing is the right approach to therapy, and then the sex life is getting better quickly.

INN: Trazodone

Manufacturer: Aziende Kimike Riunite Angelini Francesco A.K.R.A.F. S.p.A

Anatomical-therapeutic-chemical classification: Trazodone

Registration number in the Republic of Kazakhstan: No. RK-LS-5 No. 019504

Registration period: 06.04.2018 - 06.04.2023

Instruction

Tradename

Trittiko

International non-proprietary name

Trazodone

Dosage form

Extended release tablets, 150 mg

Composition

One tablet contains

active substance - trazodone hydrochloride 150 mg,

Excipients: sucrose, carnauba wax, povidone, magnesium stearate.

Description

Tablets are white or white with a yellowish tinge, oval-shaped with two parallel risks on both sides.

Pharmacotherapeutic group

Psychoanaleptics. Other antidepressants.

ATX code N06AX05

Pharmacological properties

Pharmacokinetics

Absorption of the drug from the gastrointestinal tract (GIT) after oral administration is high. Taking trazodone during or immediately after a meal slows down the absorption rate, reduces the maximum concentration of the drug in the blood plasma and increases the time to reach the maximum concentration (hereinafter referred to as TCmax). TCmax of the drug is reached after ½ - 2 hours after ingestion.

The drug penetrates through histohematic barriers, as well as into tissues and fluids (bile, saliva, breast milk).

Communication with plasma proteins - 89-95%.

Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine. The half-life is 3-6 hours, in the second phase - 5-9 hours. Most of the metabolized drug is excreted through the kidneys, about 75% is excreted in the urine and is completely completed 98 hours after ingestion, about 20% is excreted in the bile.

Pharmacodynamics

Trittico, being a derivative of triazolopyridine, has a predominantly antidepressant effect, with some sedative and anxiolytic effects.

Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, frequent urination, sweating, hyperventilation).

Trittiko is effective in sleep disorders in patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.

Trittiko stabilizes the emotional state, improves mood, reduces the pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, as well as in remission. With withdrawal symptoms in patients suffering from dependence on benzodiazepine derivatives, Trittiko is effective in the treatment of anxiety-depressive conditions and sleep disorders. During remission, benzodiazepines can be completely replaced by Trittiko.

Promotes the restoration of libido and potency both in patients with depression and in those who do not suffer from depression.

The mechanism of action of Trittiko is associated with the high affinity of the drug for certain subtypes of serotonin receptors, with which Trittiko enters into antagonistic or agonistic interaction depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.

Neutral uptake of norepinephrine and dopamine is little affected.

Indications for use

Depressive disorders, with or without:

Anxiety

sleep disorder

Sexual dysfunctions of non-organic etiology

Dosage and administration

The drug is intended exclusively for adults.

adults

The drug should be taken orally 30 minutes before a meal or 2-4 hours after a meal. When taken after a meal, the development of undesirable effects is slowed down (re-absorption increases and peak plasma concentration decreases). Tablets should be taken without chewing, drinking plenty of water.

Tablets can be divided into 3 parts in order to select the optimal dose depending on the severity of the disease, age and general condition of the patient.

The initial dose of the drug is 50-100 mg, taken once at bedtime after meals. On the 4th day, you can increase the dose to 150 mg. Further increase in dosage in order to achieve the optimal therapeutic effect should be made by 50 mg / day every 3-4 days until the optimal dose is reached. A daily dose of more than 150 mg should be divided into 2 doses, with a smaller dose taken after dinner, and the main dose at bedtime.

The maximum daily dose for outpatients is 450 mg.

The maximum daily dose for inpatients is 600 mg.

elderly people

For the elderly and debilitated people, the initial dose is up to 100 mg / day in divided doses or once at bedtime. It can be increased under the supervision of a physician, depending on the effectiveness and tolerability of the drug. Doses in excess of 300 mg/day are usually not required.

Patients with liver failure

Trittiko undergoes intensive hepatic metabolism.

Patients with renal insufficiency

As a rule, individual dosage adjustment is required, however, it is recommended to exercise caution when taking Trittiko in patients with severely impaired renal function.

Trittiko should be used in therapeutic cycles of at least one month.

Children

The safety of Trittico in children under 18 years of age has not been established. Therefore, the use of the drug by children and adolescents is not recommended.

Side effects

Possible

Fatigue, weakness, drowsiness, agitation, headache, dizziness, decreased vigilance, disorientation, tremor, memory disorder, myoclonus, expressive aphasia, paresthesia, dystonia, epileptic seizures, narcoleptic malignant syndrome

Suicidal thoughts, or suicidal behavior, confused

states, mania, feeling of fear, nervousness, agitation (usually aggravated to delirium), delirium, aggressive reaction

Withdrawal withdrawal syndrome

Nasal congestion, dyspnea

Palpitations, decreased blood pressure, orthostatic hypertension

(especially in persons with vasomotor lability), due to the adrenolytic effect of the drug, arrhythmia, ventricular extrasystoles, tachycardia, including ventricular paroxysmal, conduction disturbance, bradycardia, ECG disturbances (increased QT interval)

Decreased or increased appetite, anorexia, dryness and bitterness in the mouth,

change in taste sensations, increased salivation, nausea, vomiting, diarrhea, abdominal pain, weight loss, gastroenteritis, paralytic ileus

Pain in limbs, back pain, myalgia, arthralgia

Urination disorder

Itching, erythematous rash

Flu-like syndrome, chest pain, fever

Leukopenia, neutropenia, agranulocytosis, thrombocytopenia,

eosinophilia (usually minor), anemia

Syndrome of inappropriate secretion of antidiuretic hormone

Increasing the content of liver enzymes

Hyperhidrosis

Eye irritation

Priapism (patients who experience this side effect,

should immediately stop taking the drug and consult a doctor)

Contraindications

Hypersensitivity to the active substance or any

excipient

Alcohol or hypnotic intoxication

Acute heart failure

Pregnancy and lactation

Drug Interactions

The sedative effects of antipsychotic, hypnotic, sedative, anxiolytic and antihistamine drugs may increase, in these cases it is necessary to reduce the dosage.

The hepatic effects of oral contraceptives, phenytoin, carbamazepine, and barbiturates accelerate the metabolism of antidepressants, while cimetidine and other antipsychotics inhibit it.

Cytochrome enzyme inhibitors

There is a potential pharmacological interaction with the simultaneous use of Trittiko and cytochrome inhibitors such as erythromycin, ketoconazole, itraconazole, ritonavir, indinavit and nefazadone. Cytochrome inhibitors can contribute to a significant increase in plasma concentrations of trazodone.

Co-administration of Trittico and strong inhibitors of cytochromes should be avoided or a lower dose of the drug should be prescribed.

Carbamazepine

Plasma concentrations of trazodone are reduced by concomitant administration of carbamazepine. Concomitant use of carbamazepine resulted in a reduction in levels of trazodone and its active metabolite, metachlorphenylpiperazine, by 76% and 60%, respectively. Therefore, patients who take Trittiko and carbamazepine concomitantly should be closely monitored to assess the need for higher dosages.

Tricyclic antidepressants

The simultaneous use of Trittico and tricyclic antidepressants is not recommended, due to the possible risk of interaction. Perhaps the development of serotonergic syndrome and adverse reactions from the cardiovascular system.

fluoxetine

Rare cases of increased plasma levels of trazodone and the development of adverse reactions have been reported while taking Trittiko and fluoxetine. The mechanism of their pharmacokinetic interaction is unclear. Serotonin syndrome may result from this pharmacodynamic interaction.

Monoamine oxidase (MAO) inhibitors

The simultaneous appointment of Trittiko and monoamine oxidase inhibitors, as well as the appointment of Trittiko earlier than two weeks after the abolition of monoamine oxidase inhibitors, is strongly not recommended. It is also not recommended to prescribe monoamine oxidase inhibitors earlier than one week after discontinuation of the drug, since MAO inhibitors increase the risk of side effects of Trittiko.

Phenothiazines

With the simultaneous administration of Trittico with phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perphenazine), severe orthostatic hypertension was observed.

Muscle relaxants and gaseous anesthetics

Trittico may enhance the effect of muscle relaxants and gaseous anesthetics.

Antihypertensive drugs

Trittico may enhance the effect of some antihypertensive drugs and usually requires a reduction in their doses.

Antihistamines and drugs with anticholinergic activity enhance the anticholinergic effect of Trittico.

When Trittiko is used with digoxin and phenytoin, the concentration of these drugs in the blood plasma increases.

Undesirable effects may be more frequent when taking Trittiko together with medicines containing certain medicinal plants such as St. John's wort.

In patients treated with Trittico and warfarin, cases of altered prothrombin time have been reported.

special instructions

Use by children and adolescents under the age of 18

As a general rule, Trittiko should not be taken by children and adolescents under 18 years of age.

In clinical studies conducted with the participation of children and adolescents, cases of suicidal behavior (suicide attempts, suicidal thoughts) and hostility (significant aggressiveness, conflict behavior and anger) occurred more often in those treated with antidepressants compared to those who took placebo.

Moreover, there are no data on the safety of long-term effects of Trittico in children and adolescents, including growth, maturation, cognitive and behavioral development.

Suicide/suicidal ideation or clinical deterioration

Depression associated with an increased risk of suicidal thoughts, self-harm and suicide. The risk exists until there is a significant weakening of the disease. Since improvement may not occur during the first few weeks of treatment or more, patients should be closely monitored until improvement occurs. Clinical experience shows that the risk of suicide may increase in the early stages of recovery.

To reduce the potential risk of suicide attempts, especially at the beginning of therapy, the dosage of Trittiko given at each patient visit should be gradually reduced.

The drug should be administered with caution to patients with AV blockade of varying severity, myocardial infarction (in the early recovery period), arterial hypertension (dose adjustment of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, with renal and / or hepatic insufficiency.

Special attention to dosage and regular monitoring of elderly patients suffering from prostatic hypertrophy, urination disorders, angle-closure glaucoma, hyperthyroidism is recommended.

If you experience prolonged and inadequate erections, you should consult a doctor.

When using Trittiko, a slight decrease in the number of leukocytes is possible, which does not require specific treatment, except in cases of severe leukopenia. Developing agranulocytosis can manifest itself with symptoms characteristic of influenza. Therefore, it is recommended to conduct studies of peripheral blood, especially in the presence of pain in the throat when swallowing and the appearance of fever.

In patients with schizophrenia or various psychiatric disorders, antidepressants may exacerbate psychotic symptoms. Paranoid thoughts may develop more intensely. With Trittiko therapy, depressive episodes can range from manic-depressive to manic psychosis. In this situation, it is necessary to interrupt the treatment.

During treatment, you should refrain from drinking alcohol.

Trittiko contains sucrose, so patients with hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency should not take this medicine.

Features of the effect of the drug on the ability to drive vehicles and work with potentially dangerous mechanisms

You should refrain from engaging in potentially hazardous activities that require concentration and quick psychomotor reactions, as the drug has anxiolytic and sedative activity.

Overdose

Symptoms: drowsiness, dizziness, nausea, vomiting, increased frequency and severity of side effects. In more severe cases, tachycardia, arterial hypotension, hyponatremia, convulsions, respiratory failure, coma are possible.

Treatment: there is no specific antidote for the drug. In cases of overdose, administration of activated charcoal should be considered for those who have taken more than 1 g of trazodone within one hour. Alternatively, gastric lavage may be administered within one hour of overdosing.

In case of an overdose, the patient should be closely monitored for at least 6-12 hours after taking the drug. Control of pulse and arterial pressure is required.

Release form and packaging

10 or 20 tablets are placed in a blister pack made of PVC film and aluminum foil.

1 blister pack of 20 tablets or 2 blister packs of 10 tablets each, together with instructions for medical use in the state and Russian languages, is placed in a cardboard box.