Tablets "Neurodiclovit": instructions for use, price, analogues, indications for use, reviews about the drug of doctors and patients. Neurodiclovit analogues Neurodiclovit analogues are cheaper

In this article, you can read the instructions for using the drug Neurodiclovitis. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Neurodiclovit in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Neurodiclovit analogues in the presence of existing structural analogues. Use for the treatment of pain and inflammation in arthritis, arthrosis, sciatica, lumbago in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Neurodiclovitis- non-steroidal anti-inflammatory drug (NSAID) in combination with B vitamins. Diclofenac has anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Indiscriminately inhibiting COX-1 and COX-2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the focus of inflammation. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac contributes to a significant decrease in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. With injuries, in the postoperative period, diclofenac reduces pain and inflammatory edema.

Thiamine (vitamin B1) in the human body as a result of phosphorylation processes turns into cocarboxylase, which is a coenzyme of many enzymatic reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism. Actively participates in the processes of nerve excitation in synapses.

Pyridoxine (vitamin B6) is necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, it is a coenzyme in the metabolism of amino acids (decarboxylation, transamination). It acts as a coenzyme for the most important enzymes that act in nerve tissues. Participates in the biosynthesis of many neurotransmitters - such as dopamine, serotonin, norepinephrine, epinephrine, histamine and GABA.

Cyanocobalamin (vitamin B12) is necessary for normal hematopoiesis and maturation of red blood cells, and also participates in a number of biochemical reactions that ensure the vital activity of the body - in the transfer of methyl groups, in the synthesis of nucleic acids, protein, in the metabolism of amino acids, carbohydrates, lipids. It has a beneficial effect on processes in the nervous system (nucleic acid synthesis and lipid composition of cerebrosides and phospholipids). The coenzymatic forms of cyanocobalamin, methylcobalamin and adenosylcobalamin, are essential for cell replication and growth.

The combination of B vitamins potentiates the analgesic effect of diclofenac.

Compound

Diclofenac sodium + Thiamine hydrochloride (vitamin B1) + Pyridoxine hydrochloride (vitamin B6) + Cyanocobalamin (vitamin B12) + excipients.

Pharmacokinetics

Diclofenac

Absorption of diclofenac is fast and complete. Food slows down the rate of absorption by 1-4 hours and reduces Cmax by 40%. Plasma concentration is linearly related to the dose taken. Bioavailability - 50%. Changes in the pharmacokinetics of diclofenac against the background of repeated administration are not observed, do not cumulate. Plasma protein binding - more than 99% (most associated with albumin). Penetrates into the synovial fluid. Diclofenac is excreted in breast milk. 50% of the active substance is metabolized during the "first pass" through the liver. Metabolism occurs as a result of multiple or single hydroxylation and conjugation with glucuronic acid. The CYP2C9 isoenzyme takes part in the metabolism of the drug. The pharmacological activity of metabolites is lower than that of diclofenac. The concentration of diclofenac in the synovial fluid 4-6 hours after taking the drug is greater than in plasma, and remains higher than plasma values ​​for another 12 hours. The relationship between the concentration of the drug in the synovial fluid and the clinical efficacy of the drug has not been elucidated. 65% of the administered dose is excreted as metabolites by the kidneys, less than 1% is excreted unchanged, the rest of the dose is excreted as metabolites in the bile.

Vitamins B1, B6, B12

The vitamins that make up Neurodiclovit are water-soluble, which excludes the possibility of their accumulation in the body.

Thiamine and pyridoxine are absorbed in the upper small intestine, metabolized in the liver and excreted by the kidneys (about 8-10% unchanged). The degree of absorption depends on the dose, with an overdose, the excretion of thiamine and pyridoxine through the intestine increases significantly.

The absorption of cyanocobalamin depends to a large extent on the presence of an internal factor in the body (in the stomach and upper small intestine), further delivery of the vitamin to the tissues is determined by the transport protein transcobalamin. After metabolism in the liver, cyanocobalamin is excreted mainly with bile, the degree of excretion by the kidneys is variable - from 6 to 30%.

Indications

• pain syndrome with inflammation of a non-rheumatic nature (after injuries, surgical and dental interventions; with gynecological diseases - primary algomenorrhea, adnexitis; with inflammatory diseases of the upper respiratory tract - pharyngitis, tonsillitis, otitis media);
• inflammatory and degenerative diseases of the joints and spine (chronic polyarthritis, rheumatic and rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondylarthrosis);
• neuritis and neuralgia (cervical syndrome, lumbago, sciatica);
• acute gouty arthritis;
• rheumatic soft tissue injury.

Release form

Retard modified-release capsules (sometimes erroneously called tablets).

Other dosage forms, whether injections in injection ampoules, ointment, cream or gel, did not exist at the time of publication of the drug in the Directory.

Instructions for use and dosage

Capsules should be taken orally with meals, without chewing and with plenty of liquid.

Usually prescribed 1 capsule 1-3 times a day.

Neurodiclovit adults are prescribed 1 capsule: at the beginning of treatment - 3 times a day, as a maintenance dose - 1-2 times a day. The duration of therapy depends on the nature and severity of the disease.

Side effect

• epigastric pain;
• feeling of bloating;
• diarrhea, constipation;
• nausea, vomiting;
• flatulence;
• increased levels of liver enzymes;
• peptic ulcer with possible complications (bleeding, perforation);
• gastrointestinal bleeding;
• jaundice;
• melena;
• the appearance of blood in the stool;
• damage to the esophagus;
• aphthous stomatitis;
• dry mucous membranes (including the mouth);
• hepatitis (possibly fulminant course);
• liver necrosis;
• cirrhosis;
• hepatorenal syndrome;
• change in appetite;
• pancreatitis;
• cholecystopancreatitis;
• colitis;
• headache;
• dizziness;
• sleep disturbance;
• drowsiness;
• depression;
• irritability;
• aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases);
• convulsions;
• general weakness;
• disorientation;
• nightmares;
• feeling of fear;
• noise in ears;
• blurred vision;
• taste disorder;
• reversible or irreversible hearing loss;
• skin itching;
• skin rash;
• alopecia (baldness);
• hives;
• eczema;
• toxic dermatitis;
• erythema multiforme exudative (including Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• increased photosensitivity;
• petechial hemorrhages;
• bullous eruptions;
• fluid retention;
• nephrotic syndrome;
• proteinuria;
• oliguria;
• hematuria (blood in the urine);
• interstitial nephritis;
• papillary necrosis;
• acute renal failure;
• azotemia;
• anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis;
• thrombocytopenic purpura;
• cough;
• bronchospasm;
• swelling of the larynx;
• pneumonia;
• increase in blood pressure;
• congestive heart failure;
• extrasystole;
• chest pain;
• myocardial infarction;
• anaphylactoid reactions;
• anaphylactic shock (usually develops rapidly);
• swelling of the lips and tongue;
• allergic vasculitis;
• worsening of the course of infectious processes (including the development of necrotizing fasciitis).

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
• gastrointestinal bleeding;
• intracranial bleeding;
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nasal mucosa and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
• hematopoietic disorders;
• violations of hemostasis (including hemophilia);
• inflammatory bowel disease;
• severe liver failure;
• active liver disease;
• severe renal failure (CC less than 30 ml / min);
• progressive kidney disease;
• severe heart failure;
• the period after coronary artery bypass grafting;
• confirmed hyperkalemia;
• pregnancy;
• lactation period (breastfeeding);
• childhood;
• hypersensitivity to the components of the drug;
• hypersensitivity to other NSAIDs or vitamins.

With caution: peptic ulcer of the stomach and duodenum, ulcerative colitis, Crohn's disease, a history of liver disease, hepatic porphyria, chronic liver failure, chronic heart failure, arterial hypertension, a significant decrease in BCC (including after extensive surgery), elderly patients (including those receiving diuretics, debilitated patients and those with low body weight), bronchial asthma, simultaneous use of glucocorticosteroids (GCS) (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), ischemic heart disease, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, chronic renal insufficiency (CC 30-60 ml / min), the presence of Helicobacter pylori infection, long-term use of NSAIDs, alcoholysis m, severe somatic diseases, smoking.

Use during pregnancy and lactation

The drug Neurodiclovit is contraindicated during pregnancy and lactation (breastfeeding).

Due to the negative effect on fertility, it is not recommended to prescribe the drug to women planning to become pregnant.

In patients with infertility (including those undergoing examination), it is recommended to discontinue the drug.

Use in children

Contraindicated in childhood.

Use in elderly patients

With caution, the drug should be prescribed to elderly patients.

special instructions

During the period of treatment with the drug, systematic monitoring of the picture of peripheral blood, liver and kidney function, and examination of feces for the presence of blood should be carried out.

To reduce the risk of adverse events in the gastrointestinal tract, Neurodiclovit should be used at the lowest effective dose for the shortest possible course.

In order to quickly achieve the desired therapeutic effect, the tablets are taken 30 minutes before a meal. In other cases, take before, during or after a meal, without chewing, drinking plenty of water.

Due to the important role of prostaglandins in maintaining renal blood flow, special care should be taken when prescribing to patients with heart or kidney failure, as well as in the treatment of elderly patients receiving diuretics, and patients who, for any reason, have a decrease in BCC (including hours after extensive surgery). If diclofenac is prescribed in such cases, it is recommended to monitor renal function as a precautionary measure.

If, while taking the drug, an increase in liver transaminase activity persists or increases, if clinical symptoms of hepatotoxicity (including nausea, fatigue, drowsiness, diarrhea, pruritus, jaundice) are noted, treatment should be discontinued.

Diclofenac (like other NSAIDs) can cause hyperkalemia.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, a decrease in the rate of mental and motor reactions is possible, therefore, patients should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

drug interaction

With the simultaneous use of Neurodiclovit increases the plasma concentration of digoxin, methotrexate, lithium preparations and cyclosporine.

With the simultaneous use of Neurodiclovit reduces the effect of diuretics, against the background of potassium-sparing diuretics, the risk of hyperkalemia increases.

With the simultaneous use of Neurodiclovit and anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding (often gastrointestinal bleeding) increases.

With the simultaneous use of Neurodiclovit reduces the effects of antihypertensive and hypnotic drugs.

With the simultaneous use of Neurodiclovit increases the likelihood of side effects of other NSAIDs and corticosteroids (gastrointestinal bleeding), methotrexate toxicity and cyclosporine nephrotoxicity.

Acetylsalicylic acid (Aspirin) reduces the concentration of diclofenac in the blood.

Simultaneous use of Neurodiclovit with paracetamol increases the risk of nephrotoxic effects of diclofenac.

With the simultaneous use of Neurodiclovit reduces the effect of hypoglycemic agents.

With simultaneous use with Neurodiclovit, cefamandol, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia.

Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases the risk of nephrotoxicity.

The simultaneous appointment of Neurodiclovit with ethanol (alcohol), colchicine, corticotropin, serotonin reuptake inhibitors and St. John's wort increases the risk of gastrointestinal bleeding.

Diclofenac enhances the effect of drugs that cause photosensitivity.

Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.

Neurodiclovit reduces the antiparkinsonian efficacy of levodopa.

Ethanol (alcohol) dramatically reduces the absorption of thiamine (blood levels can drop by 30%).

Long-term treatment with anticonvulsants can lead to thiamine deficiency.

The use of colchicine and biguanides reduces the absorption of cyanocobalamin.

Analogues of the drug Neurodiclovit

Neurodiclovit has no structural analogues for the active substance. The combination of active ingredients in the composition of the drug is unique and has no analogues.

Analogues for the therapeutic effect (drugs for the treatment of sciatica):

• Alvipsal;
• Apizartron;
• Acylpyrine;
• Bengay;
• Betalgon;
• Bralangin;
• Brufen;
• Voltaren;
• Voltaren Emulgel;
• Dexalgin;
• Diklobene;
• Diclovit;
• Dicloran;
• Diclofenac;
• Diprospan;
• Long;
• Indomethacin;
• Adhesive plaster medical Nanoplast forte;
• Maxigan;
• Nise;
• Neuromultivit;
• Nimesulide;
• Niflugel;
• Plivalgin;
• Rapten Duo;
• Revalgin;
• Sanaprox;
• Spazgan;
• Spazmalgon;
• Surgam;
• Texamen;
• Tenoctil;
• Fastum gel;
• Finalgon;
• Flamadex;
• Flamax;
• Flexen;
• Cefekon;
• Efkamon;
• Unispaz.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

This page provides a list Neurodiclovit analogues- these are interchangeable drugs that have similar indications for use and belong to the same pharmacological group. Before you buy analog Neurodiclovit, it is necessary to consult with a specialist regarding the replacement of the drug, study in detail, read and a similar drug.

• Kapsikam

  Kapsikam effective for sciatica, osteochondrosis (a disease of the spine associated with metabolic disorders in the intervertebral discs and bone tissue), arthritis (inflammation of the joint), neuralgia (pain that spreads along the nerve), warming massage in athletes.

• Dolobene

  Gel Dolobene applies to:
  - hematomas and inflammation of soft tissues, muscles, tendons, tendon sheaths, ligaments after bruises, pressure, trauma;
  - neuralgia;
  - joint injuries with sprain or rupture of ligaments;
  - humeroscapular periarthritis, epicondylitis of the shoulder ("tennis elbow"), tendonitis, tendovaginitis, bursitis;
  - arthritis, deforming osteoarthritis (with concomitant lesions of periarticular tissues);
  - superficial thrombophlebitis, trophic ulcers against the background of chronic venous insufficiency.

• Fir oil

  Fir oil has antimicrobial, antiviral, anti-inflammatory, tonic, restorative, analgesic and sedative effects. Fir oil affects the cardiovascular and central nervous system; improves the function of the gastrointestinal tract; lowers blood pressure; stimulates the body's defenses; improves sleep; eliminates the effects of stress factors; activates the functions of the gonads and the entire endocrine system; accelerates the recovery of forces and rejuvenates the body.

• Aspirin-S

  Aspirin-S indicated for pain syndromes of low and moderate intensity of various, including inflammatory, genesis (origin), in particular, headache, toothache, algomenorrhea (painful menstruation). Feverish conditions (a sharp rise in body temperature), including acute respiratory (respiratory) infections. Thrombophlebitis (blockage of blood vessels with a blood clot). Thrombosis (formation of a blood clot in a vessel) of retinal vessels. Cerebral circulation disorders. Cardiac ischemia.

• Migrenol

  Migrenol It is used to eliminate pain syndrome of mild and moderate severity: headache, migraine, toothache, muscle and rheumatic pain, muscle pain, painful menstruation.

  Migrenol also used for the symptomatic treatment of colds and flu to reduce elevated body temperature.

• Sedalgin

  A drug Sedalgin It is intended for the symptomatic treatment of pain syndrome in:
  - migraine, tension headache;
  - inflammatory and degenerative diseases of the musculoskeletal system;
  - postoperative conditions;
  - diseases of the peripheral nervous system (sciatica, plexitis, neuritis, neuralgia, polyneuritis, polyneuropathy);
  - dysmenorrhea.

• Traumeel S

  homeopathic remedy Traumeel S used for the treatment of dislocations, sprains, bone fractures, swelling of soft tissues after operations and injuries; inflammatory processes of various organs and tissues, especially the musculoskeletal system (tendovaginitis, bursitis, styloiditis, epicondylitis, periarthritis).

• Adam Root

  Healing balm Adam's root:
  - activates tissue regeneration,
  - has a pronounced distracting, warming effect,
  - normalizes mineral and carbohydrate metabolism in tissues,
  - activates the activity of skin receptors,
  - restores the energy balance of cells.

• Antral

  Antral used to treat both adults and children with acute and chronic hepatitis of various origins (drug-induced, viral, toxic, alcoholic), liver cirrhosis and fatty degeneration; with inflammatory diseases of the pancreas, gallbladder, spleen; resection of the gallbladder. In order to prevent liver diseases caused by the negative effects of toxins of various etiologies: chemotherapy, radiation therapy, alimentary toxins, drugs.
  

• Panadol children's candles

  Panadol children's candles used in children from 3 to 6 years old (with a body weight of 13 to 20 kg) as an antipyretic: colds, influenza, childhood infectious diseases (chickenpox, rubella, whooping cough, measles, scarlet fever and mumps (mumps), after vaccination, as an analgesic: teething, toothache, earache with otitis media, sore throat.
  Children's Panadol candles are indicated for children who have difficulty taking pills or who are prone to vomiting.
  

• Nurofen syrup for children

  Nurofen indicated for children from 3 months to 12 years: as an antipyretic - acute respiratory infections, acute respiratory viral infections, influenza, other infectious and inflammatory diseases, accompanied by fever; post-vaccination reactions; as an analgesic - pain syndrome of mild or moderate intensity (including headache and toothache, migraine, neuralgia, pain in the ears and throat, pain with sprains), etc.
  

• Buprenorphine

  Buprenorphine are: pain syndrome (strong and moderate intensity): in cancer patients, postoperative pain, angina pectoris, myocardial infarction, renal colic, burns.
  

• Butorphanol

  Indications for the use of the drug Butorphanol are: pain syndrome of various origins (medium and severe intensity); premedication before general anesthesia; as a component for intravenous general anesthesia; pain relief during childbirth.
  

• Paracetamol

  Indications for the use of the drug Paracetamol are: pain syndrome of mild and moderate intensity of various origins (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain from injuries, burns). Increased body temperature with colds and other infectious and inflammatory diseases.
  

• Ibuprom

  Indications for the use of the drug Ibuprom are: pain of low and medium intensity of various origins (headache, toothache, painful menstruation, pain in the lower back, muscle pain, pain in rheumatic lesions of bones and joints). Fever.
  

• Viburkol

• Dolaren

  Indications for the use of the drug Dolaren are: short-term therapy of pain syndrome in rheumatic diseases (rheumatoid arthritis, osteoarthritis). Neuralgia, myalgia, lumboischalgia, post-traumatic pain syndrome accompanied by inflammation, postoperative pain, headache, migraine, algomenorrhea, adnexitis, proctitis, toothache.
  As part of the complex therapy of infectious and inflammatory diseases of the ear, throat, nose with severe pain and fever syndrome (pharyngitis, tonsillitis, otitis media).
  

• Rapten duo

  A drug Rapten duo used for the short-term treatment of pain associated with the following conditions:
  Symptomatic treatment of diseases of the musculoskeletal system (including rheumatoid arthritis, psoriatic arthritis, juvenile chronic arthritis, ankylosing spondylitis (Bekhterev's disease); gouty arthritis, osteoarthritis of the peripheral joints and spine, including those with radicular syndrome, tendovaginitis, bursitis;
  Pain syndrome: pain and inflammatory conditions in gynecology: algomenorrhea (painful menstruation), adnexitis (inflammation of the uterine appendages), post-traumatic and postoperative pain syndrome, accompanied by inflammation, pain in oncological diseases, headache, migraine, toothache; neuralgia, myalgia, lumbago, sciatica, ossalgia;
  As part of the complex therapy of infectious and inflammatory diseases of the ear, throat, nose with severe pain syndrome (pharyngitis, tonsillitis, otitis media).
  

• Cefekon N

  Cefekon N used as an anesthetic for mild to moderate pain syndrome: neuralgia, myalgia, sciatica, lumbago; degenerative-dystrophic diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, ankylosing spondylitis); headache and toothache, migraine; primary algomenorrhea; as an antipyretic: febrile syndrome with colds, infectious, inflammatory diseases.
  

• Acelizin

  Indications for the use of the drug Acelizin are: pain of various origins: headache, ear and toothache, myalgia, neuralgia, arthralgia, pain in the postoperative period, as an antipyretic agent for febrile conditions of various etiologies, as an antiplatelet agent for the prevention of thrombosis in cardiology and neurology, as well as for the prevention of microcirculation disorders .
  

• Daleron S Junior

  Daleron S Junior indicated for admission in childhood as: an antipyretic agent for infectious and inflammatory (bacterial, viral) diseases, as well as after vaccination; an anesthetic for acute pain (headache, toothache), muscle and joint pain in infectious and inflammatory (bacterial, viral) diseases; pain reliever for injuries, medical or dental interventions.
  

• Upsarin UPSA

  Indications for the use of the drug Upsarin UPSA are: moderate or mild pain syndrome of various origins in adults: headache (including those associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, thoracic radicular syndrome, myalgia and joint pain, pain during menstruation, fever during colds and other infectious and inflammatory diseases (in adults and children over 15 years of age).
  

• Farmadol

  Farmadol appoint: as an analgesic for the relief of mild or moderate pain; as an antipyretic for diseases of any etiology, accompanied by fever; with migraine, headache, toothache, neuralgia, rheumatic diseases, arthralgia, primary dysmenorrhea.
  

• Efferalgan (children's)

  A drug Efferalgan used to treat children aged 1 month to 12 years, suffering from pain of mild to moderate intensity (toothache, myalgia, headache, pain during teething).
  The drug is also prescribed for the treatment of fever of various etiologies.
  

• Askofen-P

  Askofen-P applies:
  - In adults, to relieve pain of mild to moderate intensity (headache, including migraine, toothache, muscle, joint pain, neuralgia, thoracic radicular syndrome, lumbago, algomenorrhea).
  - In adults and children (over 15 years old), it can be used for "colds" and other infectious and inflammatory diseases as an antipyretic.
  

• Next

  Indications for the use of the drug Next are: headache (including migraine); toothache; algomenorrhea (painful menstruation); neuralgia; myalgia; back pain; joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system; pain with bruises, sprains, dislocations, fractures; post-traumatic and postoperative pain syndrome; febrile conditions (including flu and colds).
  

• Pentalgin

  A drug Pentalgin is indicated for the treatment of pain syndrome of various origins, including pain in the joints, muscles, sciatica, menstrual pain, neuralgia, toothache and headache (including headache caused by spasm of cerebral vessels).
  Pain associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic.
  Post-traumatic and postoperative pain syndrome, including accompanied by inflammation.
  Colds, accompanied by febrile syndrome (as a symptomatic therapy).

• Analgin

  Indications for the use of the drug Analgin are:
  - Weak or moderate pain syndrome (headache, migraine, toothache, neuralgia, myalgia; dysmenorrhea; postoperative pain.
  - In combination with antispasmodics for renal and biliary colic).
  - Feverish conditions in infectious and inflammatory diseases.
  - Use as an antipyretic agent is advisable after the diagnosis of the disease.
  

• Citramon P

  Indications for the use of the drug Citramon P are:
  - Pain syndrome of mild and moderate severity (of various origins): headache; migraine; toothache; neuralgia; myalgia; arthralgia; algomenorrhea.
  - Feverish syndrome: with acute respiratory infections; with the flu.
  

• Transtec

  Transtec used in the treatment of patients with prolonged and severe pain on the background of oncological pathologies.
  Transtec can also be used in the treatment of patients with pain that is not relieved by non-steroidal anti-inflammatory drugs (excluding acute pain).

• Pentalgin Plus

  A drug Pentalgin Plus is indicated for use in moderately severe pain syndrome of various origins, including pain in the joints and muscles, algomenorrhea, neuralgia, post-traumatic pain, as well as headache and toothache. Pentalgin Plus can be used as a symptomatic remedy for febrile syndrome.
  

• Maxigan

  A drug Maxigan is intended to eliminate mild or moderate pain syndrome with spasms of smooth muscles of internal organs - renal and hepatic colic, spastic pain along the intestines, algomenorrhea. It can be used for short-term symptomatic treatment of joint pain, neuralgia, sciatica, myalgia.
  As an aid, it can be used to reduce pain after surgical and diagnostic interventions. If necessary, the drug can be used to reduce elevated body temperature in colds and infectious and inflammatory diseases.
  

• Femizol

  A drug Femizol is intended for relief of such symptoms of premenstrual syndrome as: bloating, weight gain due to fluid retention in the body, headaches and back pain.
  

• Nurofen Long

  Indications for the use of the drug Nurofen Long are: back pain, joint pain, muscle and rheumatic pain, neuralgia, headache, migraine, toothache, painful menstruation, sore throat, fever, cold and flu symptoms.
  A drug Nurofen Long especially indicated for the symptomatic treatment of pain requiring a more pronounced analgesic effect than ibuprofen or paracetamol alone.
  

• Citramarine

  Indications for the use of the drug Citramarine are:
  - Fever syndrome: in acute influenza and respiratory disease.
  - Pain syndrome of mild and moderate severity (of various origins): neuralgia; headache; migraine; algomenorrhea; toothache; myalgia; arthralgia.
  

• Excedrin

  A drug Excedrin is intended for use to eliminate pain syndrome of moderate and mild intensity of various origins: headache, migraine, toothache, neuralgia, arthralgia and myalgia (pain in the muscles and joints), algomenorrhea (pain during menstruation).
  

• Nurofen Plus

  A drug Nurofen Plus is intended for short-term symptomatic treatment of pain syndrome of mild to moderate severity (headache, migraine, toothache, neuralgia, back pain, painful menstruation, muscle and rheumatic pains) with the ineffectiveness of NSAID monotherapy.
  

• Naproff

  Indications for the use of the drug Naproff are: headache and toothache, migraine, menstrual pain; muscle, joint and spinal pain (musculoskeletal disorders); post-traumatic pain (sprain, bruises, strain); postoperative pain (in traumatology, orthopedics, gynecology, surgical dentistry); rheumatic diseases (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout).
  

• Aspirin Complex

  Aspirin Complex use to relieve symptoms of "colds", SARS, influenza, such as: high fever and chills, headache and muscle pain, runny nose and / or nasal congestion, sore throat and sneezing.
  

• Aspirin

  A drug Aspirinused for symptomatic treatment of headache, toothache; sore throat due to a cold; algomenorrhea; pain in muscles and joints; back pain moderate pain due to arthritis.
  Aspirineffective for colds or acute respiratory diseases; for symptomatic relief of pain and fever.
  

• Alfort Dexa

  A drug Alfort Dexa is used in the symptomatic treatment of acute pain of moderate to severe intensity when oral administration of the drug is not advisable, for example, in postoperative pain, renal colic and back pain (back pain).
  

• Pireticol

  suspension Pireticol recommended for mild to moderate pain of various origins, including: teething pain, toothache, sore throat, fever with colds, flu and childhood infections such as chickenpox, whooping cough, measles, mumps (mumps) .
  Pireticol also recommended for the treatment of post-vaccination hyperthermia in infants aged 2-3 months.
  

• Dexonal

  Musculoskeletal pain (mild or moderate), algomenorrhea, toothache.
  A drug Dexonal intended for symptomatic treatment, reducing pain and inflammation at the time of use.
  

• artrosilene

  Indications for use capsules, suppository Artrosilene are: relief of pain of mild and moderate intensity (including pain of an inflammatory nature, postoperative and post-traumatic); rheumatic diseases: rheumatoid arthritis; spondyloarthritis; osteoarthritis; gouty arthritis; inflammatory lesions of the periarticular tissues.
  Solution for intravenous and intramuscular administration artrosilene: short-term treatment of acute pain syndrome in diseases of the musculoskeletal system of various origins, postoperative pain, post-traumatic pain associated with inflammation.
  Gel, aerosol artrosilene: diseases of the musculoskeletal system (including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis of the peripheral joints and spine, rheumatic lesions of soft tissues); muscle pain of rheumatic and non-rheumatic origin; traumatic soft tissue injuries.
  

• Rotalphen

  Indications for the use of the drug Rotalphen are:
  - relief of pain syndrome of various origins (including postoperative pain, pain with bone metastases, post-traumatic pain, pain with renal colic, algomenorrhea, sciatica, sciatica, neuralgia, toothache);
  - symptomatic treatment of acute and chronic inflammatory, inflammatory-degenerative and metabolic diseases of the musculoskeletal system (including rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis).
  

• Clodifen Neuro

  Indications for the use of the drug Clodifen Neuro are:
  - pain syndrome with inflammation of a non-rheumatic nature (after injuries, surgical and dental interventions; with gynecological diseases - primary algomenorrhea, adnexitis; with inflammatory diseases of the ENT organs - pharyngitis, tonsillitis, otitis media);
  - inflammatory and degenerative diseases of the spine and joints (rheumatoid arthritis, ankylosing spondylitis - Bechterew's disease, spondyloarthritis, spondylarthrosis, osteoarthritis);
  - neuritis and neuralgia (cervical syndrome, lumbago, sciatica);
  - acute gouty arthritis;
  - rheumatic diseases of periarticular soft tissues.
  

• Ketanov

  Ketanov is intended for use to eliminate pain syndrome of moderate and severe intensity of various origins (including in the postoperative period, with oncological diseases).

• SPAZMALGON

  Spazmalgon is intended for use in symptomatic treatment of mild and moderate pain syndrome with spasms of smooth muscles of internal organs:
  - renal colic and inflammatory diseases of the urinary tract, occurring with pain and dysuric disorders;
  - spasms of the stomach and intestines, hepatic colic, biliary dyskinesia;
  - spastic dysmenorrhea.
  

• Nimesil

  Indications for the use of the drug Nimesil are: acute pain (pain in the back, lower back; pain in the musculoskeletal system, including bruises, sprains and dislocations of the joints; tendonitis, bursitis; toothache); symptomatic treatment of osteoarthritis (osteoarthritis) with pain syndrome; primary algomenorrhea.
  A drug Nimesil intended for symptomatic therapy, reducing pain and inflammation at the time of use; nimesulide is recommended for therapy as a second-line drug.
  

• Brufica Plus

  Brufica Plus used in children from 2 years.
  As an antipyretic for: acute respiratory diseases; flu childhood infectious diseases; post-vaccination reactions and other infectious and inflammatory diseases accompanied by an increase in body temperature.
  As a mild to moderate pain reliever for: headache and toothache; migraine; neuralgia; pain in the ears and throat; muscle pain; pain from injuries, sprains, burns and other types of pain.
  

• Voltaren Akti

  tabletc Voltaren Akti apply for:
  - Removal and reduction of pain syndrome of various origins, including: headache; toothache; pain during menstruation; muscle pain; pain in various parts of the spine.
  - Removal and reduction of symptoms of colds, flu and sore throats, including pain in these conditions.
  - To reduce body temperature.
  

• Baralgin M

  A drug Baralgin M is intended for use to eliminate pain syndrome of low and moderate intensity (headache and toothache, neuralgia, pain in radiculitis, osteochondrosis, arthritis, menalgia), spasms of smooth muscles (renal colic, biliary colic, intestinal colic), febrile conditions in infectious and inflammatory diseases (as part of combination therapy).
  

• Katadolon

• DIKLOBERL

• DICLOTOL

• CAVER

• NOVIGAN

• INCENA

• DOLORMINE

• VIPRATOX

• PERSKINDOL

• DIKLOSAFE GEL

• EMLA

• Bystrumgel

  Bysrumgel indicated for use in the following pathological conditions:
  - lesions of the lumbosacral region;
  - arthritis;
  - lumbago;
  - periarthritis;
  - tendinitis;
  - ruptures of the ligamentous apparatus;
  - muscle ruptures;
  - rheumatoid arthritis;
  - lymphangitis;
  - arthrosis;
  - spondyloarthritis;
  - tendosynovitis;
  - sports injuries;
  - osteochondrosis;
  - bruises of soft tissues;
  - phlebitis;
  - bursitis;
  - damage to the meniscus;
  - torticollis;
  - sciatica;
  - dorsalgia;
  - dislocations;
  - myositis;
  - enthesopathy.

• Dexalgin

  Dexalgin shown as
  . Symptomatic treatment for toothache;
  . pain during menstruation;
  . mild or moderate pain syndrome in diseases of the musculoskeletal system.

• Xefocam

  Indications for the use of the drug Xefocam are: short-term treatment of pain syndrome of various origins. Symptomatic therapy of rheumatic diseases (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, rheumatic soft tissue damage).
  

• No-shpa

  No-shpa solution for IV and IV administration: spasms of smooth muscles associated with diseases of the biliary tract (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis); spasms of smooth muscles of the urinary tract (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus); during the period of stretching during physiological childbirth, a shortening of the phase of cervical dilatation and thereby a reduction in the total duration of labor.
  As an adjuvant therapy (if oral therapy is not possible): with spasms of smooth muscles of gastrointestinal origin (peptic ulcer of the stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis, colitis); with gynecological diseases (dysmenorrhea, strong labor pains).
  No-shpa tablets: spasms of smooth muscles associated with diseases of the biliary tract (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis); spasms of smooth muscles of the urinary tract (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus).
  As an adjuvant therapy: with spasms of smooth muscles of gastrointestinal origin (gastric ulcer and duodenal ulcer, gastritis, spasms of the cardia and pylorus, enteritis, colitis, spastic colitis with constipation and meteoric forms of mucous colitis);
  tension headaches; with gynecological diseases (dysmenorrhea).
  

• Paracetamol Extratab

• Dextanol

  Tablets Dextanol are used to eliminate pain syndrome of mild and moderate intensity in the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis); algomenorrhea; toothache.
  

• Unispaz

  A drug Unispaz is intended to eliminate pain syndrome of mild to moderate intensity: (toothache and headache, pain in the joints, muscles, neuralgia, sciatica, periodic pain in women), caused, among other things, by spasms of smooth muscles (renal colic, spasms of the ureter and urinary bladder, biliary colic, intestinal colic, spastic constipation and other spastic conditions of the internal organs).
  

• Saridon

  A drug Saridon used to relieve pain of various etiologies, including: headache, toothache, migraine pain, neuralgia, myalgia, sciatica, post-traumatic and postoperative pain, dysmenorrhea pain.
  To reduce elevated body temperature in colds and other infectious and inflammatory diseases.

• Sedal-M

  A drug Sedal-M It is used to eliminate mild and moderate pain syndrome of various origins: headache, toothache, migraine, pain in muscles and joints, neuralgia, with painful menstruation, with sciatica, with traumatic and postoperative pain.
  Sedal-M also used to reduce elevated body temperature in "colds", other infectious and inflammatory diseases and influenza.
  

• Solpadein

  Solpadein used in adults and children over 12 years of age with pain syndrome (headache, toothache, migraine, muscle and joint pain, neuralgia, painful menstruation, sciatica, sprains, sinusitis and sore throat). In adults and children over 12 years of age to reduce elevated body temperature, with "colds", other infectious and inflammatory diseases and influenza.
  

• gofen

  A drug gofen used in the symptomatic treatment of headache, toothache and menstrual pain; fever.
  

• Flamax

  NSAIDs for the treatment of pain.
  Flamax
  Inflammatory and degenerative diseases of the musculoskeletal system:
  - rheumatoid arthritis;
  - seronegative arthritis: ankylosing spondylitis (Bekhterev's disease), psoriatic arthritis, reactive arthritis (Reiter's syndrome);
  - gout, pseudogout;
  - osteoarthritis.
  Pain syndrome:
  - tendinitis, bursitis, myalgia, neuralgia, sciatica;
  - migraine;
  - post-traumatic and postoperative pain syndrome;
  - pain syndrome in oncological diseases;
  - algomenorrhea.
  

• Ibuprofen

  A drug Ibuprofen is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.
  - inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis (Bekhterev's disease).
  - pain syndrome: myalgia, arthralgia, ossalgia, arthritis, sciatica, migraine, headache (including menstrual syndrome) and toothache, neuralgia, tendonitis, tendovaginitis, bursitis, post-traumatic and postoperative pain syndrome, accompanied by inflammation, in oncological diseases;
  - algomenorrhea, inflammation in the pelvis, incl. adnexitis;
  - febrile syndrome with colds and infectious diseases.
  

Neurodiclovit is a drug that belongs to non-steroidal anti-inflammatory drugs, it contains diclofenac and B vitamins. Thanks to this combination of active substances, pain caused by neurological, musculoskeletal (sometimes gynecological and otolaryngic) diseases is reduced.

Diclofenac has anti-inflammatory, analgesic and antipyretic effects, also relieves swelling and swelling. The therapeutic effect is carried out by indiscriminate inhibition of cyclooxygenase-1 and cyclooxygenase-2, which causes a violation of the metabolism of arachidonic acid and a decrease in prostaglandins (pain mediators) in the inflammatory focus. Thus, with rheumatic pathologies, taking the drug eliminates morning stiffness, relieves inflammation and swelling of the joint.

After injury and in the postoperative period, Neurodiclovit reduces pain and swelling, prevents the development of fever.

Neurodiclovit, photo of capsules

B vitamins have effects:

1. Thiamine (B1). Participates in carbon, lipid, energy and protein metabolism, regulates the activity of the nervous system (in particular, is responsible for the mechanism of nerve impulse conduction).

2. Pyroxidine (B6). Improves the contractility of the heart muscle, promotes the conversion of folic acid into an active form. Also, the vitamin is involved in the synthesis of neurotransmitters, regulates the functioning of the nervous system, promotes the absorption of glucose by nerve cells, reduces spasms and muscle cramps, and improves the passage of impulses from receptors to the brain. In addition, pyroxidine synthesizes neurotransmitters such as dopamine, serotonin, norepinephrine, epinephrine, histamine.

3. Cyanocobalamin (B12). Participates in the hematopoietic process, the formation of neurons, has a positive effect on metabolism, synthesizes nucleic acids necessary for the normal functioning of the nervous system.

The drug is released in capsules. Ingredients: diclofenac (50 milligrams), thiamine (50 milligrams), pyroxidine (50 milligrams), cyanocobalamin (1/4 milligrams).

Indications for use

What is Neurodiclovit used for? It is prescribed for the following diseases:

• Inflammatory and degenerative-dystrophic pathologies of the ridge and bone joints, accompanied by severe pain and inflammation (osteochondrosis, spondylarthrosis, osteoarthritis, chronic polyarthritis);
• Neuritis (inflammation of the occipital, intercostal or facial nerve, as well as the nerves of the limb) and neuralgia (severe pain along the innervation of the nerve - sciatica, lumbago, trigeminal attack);
• Acute gouty arthritis;
• Rheumatic extra-articular lesion of periarticular tissues.

Also, the drug is prescribed if there is a pronounced pain syndrome after surgical or dental implantation, with painful menstruation, sore throat caused by tonsillitis, tonsillitis, pharyngitis.

Instructions for use Neurodiclovit, dosages

The drug is taken orally, the capsules are not chewed or opened. Drink enough water. Neurodiclovit is recommended to be taken immediately after a meal.

The dosage is prescribed by the attending physician on an individual basis. According to the instructions for the use of Neurodiclovit, the recommended amount is:

1. Adults, one capsule three times a day, maintenance therapy - one capsule per day;
2. Adolescents (from 12-18 years old, if body weight is more than 40 kg) one capsule twice a day, maintenance therapy - one capsule every other day;
3. Patients over 65 years of age require dosage adjustment. Before prescribing a medication, a detailed study of the function of the liver and kidneys is carried out.

If the indicators are slightly deviated to the side, then the dosage is prescribed, as for adolescents.

It should be borne in mind that the drug reduces the effect of diuretics, therefore, the risk of developing hyperkalemia (potassium release from cells and the body) increases. If the patient is being treated with coagulants or thrombolytic drugs, there is a high risk of bleeding (most often in the stomach or intestines). The effect of antihypertensive and sedative drugs is reduced if Neurodiclovit is used simultaneously with them.

Contraindications and overdose

The drug is not prescribed for the following diseases and features:

• intolerance to any component;
• the presence of the aspirin triad in history (simultaneous aspirin intolerance, nasal polyps and bronchial asthma);
• porphyrin disease (disturbance of pigment metabolism);
• diseases of the blood and blood-forming organs, including hemorrhagic diathesis (the tendency of the body to bleed and hemorrhage);
• stomach ulcer and duodenal ulcer (acute form), including perforation of the ulcer; Crohn's disease, bleeding in the stomach or intestines;
• heart failure (moderate and severe form);
• thromboembolism, erythremia, erythrocytosis;
• allergic manifestations of moderate and severe severity.

Neurodiclovit is also contraindicated in children under 12 years of age, women who are carrying a fetus and breastfeeding.

Relative contraindications include:

- seasonal fever;
- high blood pressure, ischemia, impaired peripheral and cerebral circulation;
- angina pectoris, malignant neoplasms.

During treatment, the patient may experience side effects of varying severity. Reactions to Neurodiclovitis are most often:

• heart and blood vessels (hypertension, fluid retention in the body, myocardial infarction, cardiac arrhythmias);
• from the side of the central nervous system - convulsive syndrome, sleep disturbance, migraine, trembling fingers, anxiety, deterioration of visual acuity;
• gastrointestinal system - the formation or progression of an ulcer, abdominal pain, pathological changes in stool (diarrhea or constipation), flatulence;
• urinary system - insufficiency of renal function, urinary retention, protein and hematuria;
• skin - small rash, focal redness, itching, severe hyperemia.

An overdose occurs when an incorrect dose of the drug is taken or as a result of long-term treatment with it. The patient is diagnosed with renal failure and symptoms of hepatotoxicity (nausea, vomiting, jaundice of the skin). Also, an overdose leads to the development of neurotoxic signs (neuropathy, convulsions, cardiac arrhythmias).

Neurodiclovit analogues, list of drugs

Today, there are many analogues of Neurodiclovit, the most common:

1. Dolex,
2. Naklofen,
3. Ortofen,
4. Flotak.

Important - instructions for use Neurodiclovit, price and reviews do not apply to analogues and cannot be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Neurodiclovit with an analogue, it is important to get expert advice, you may need to change the course of therapy, dosages, etc. Do not self-medicate!

Doctor's review of Neurodiclovit: “The drug perfectly relieves pain, is sold in a pharmacy without a prescription, it can even be used as an ambulance at home. However, due to the large list of contraindications, it is not prescribed for every patient, so it is necessary to prescribe analogues, the therapeutic effect of which is sometimes much worse.

Prohibited during pregnancy

Has limitations for kidney problems

The combined Austrian drug Neurodiclovit, which is manufactured by Gerot Lannach Pharma, belongs to the group of non-selective NSAIDs, it combines high efficiency with relative safety of use. The neurotropic vitamins of group B included in its composition normalize the functioning of the nervous system, have an analgesic effect, enhance the effect of the main substance, as a result of which a lower dosage is used for treatment.

The drug is produced in the form of capsules with a modified release of active substances. The composition of Neurodiclovit includes the following components:

• diclofenac sodium - 50 mg;
• thiamine hydrochloride, vitamin B1 - 50 mg;
• pyridoxine hydrochloride, vitamin B6 - 50 mg;
• cyanocobalamin, vitamin B12 - 0.25 mg.

Neurodiclovitis is indicated for the following pathologies:

• chronic diseases of the joints with pain syndrome (polyarthritis, gouty arthritis, etc.);
• back pain caused by neuritis and neuralgia;
• spondyloarthritis;
• osteocondritis of the spine;
• ankylosing spondylitis;
• pain syndromes in gynecology and dentistry;
• extra-articular rheumatism;
• post-traumatic inflammatory processes;
• swelling with pain syndrome;
• lumbago;
• sciatica.

Analogues and substitutes of Neurodiclovit do not contain the whole complex of active and excipients and have a narrower therapeutic focus, thus their cost is much lower.

Prices for the drug and its main analogues, average in Russia

Recently, many analogues of Neurodiclovit capsules have appeared on the pharmaceutical market, their prices fluctuate both in different regions and in various pharmacy chains, but on average analogues can be purchased 2 or more times cheaper.

Among them, analogues are most often offered in terms of partial composition and similar therapeutic effect, such as tablets Ketorlak, Diclofenac, Bol-Ran, Ketorol, Diklaka, Diclocaine, Ketanov, Aertala, Diclovit, Doloxen, Fanigan, Ortofen, Flamidez, Voltaren; capsules Naklofen Duo and others.

N p / p	Name of the drug	Release form	Volume	Price
1.	Neurodiclovitis	Capsule 30 pcs.	75 mg	1250
2.	Aertal	Tablets 20 pcs.	0.1 g	383
3.	Voltaren	Tablets 20 pcs.	50 mg	298
4.	Diklak	Tablets 10 pcs.	75 mg	73
5.	Diklovit	Suppositories rectal	50 mg	156
6.	Diclofenac	Tablets 20 pcs.	50 mg	46
7.	Ketanov	Tablets 100 pcs.	10 mg	195
8.	Ketorol	Tablets 20 pcs.	10 mg	37
9.	Ketorolac	Tablets 20 pcs.	10 mg	39
10.	Tablets 20 pcs.	25 mg	50

In each specific case of the disease, the doctor can select several analogues of Neurodiclovit to relieve pain syndromes and alleviate the patient's condition in various price groups.

Characteristics of common analogues based on diclofenac

Neurodiclovit analogues with the same complex composition of vitamins and NSAIDs are not produced. Substitutes with diclofenac cover only a certain part of the therapeutic indications, so it is important to choose the most effective and suitable drug from a large drug group.

Blockium B12

Manufactured in Argentina by Casasco A.P.T.T. the analogue of Neurodiclovit is not a complete analogue of the drug, it contains only one vitamin of group B. It belongs to non-steroidal anti-inflammatory and antirheumatic drugs that affect the human musculoskeletal system. It consists of:

• diclofenac potassium;
• betamethasone;
• cyanocobalamin, vitamin B12.

Blockium B12 tablets are effective for quickly relieving pain and swelling of various etiologies:

• traumatic nature (after fractures, sprains, bruises, surgery);
• gynecological (with dysmenorrhea, menstruation, adnexitis);
• rheumatic and neurological;
• colds and ENT diseases.

The drug is available in the form of tablets. Contraindicated in children under 14 years of age, with allergies to components, intolerance to nonsteroidal drugs, duodenal ulcers and stomach ulcers, renal failure, diseases of the cardiovascular system, diabetes mellitus, osteoporosis, in the second half of pregnancy and lactation.

Combined analgesic, antipyretic and anti-inflammatory drug of Indian production. Contains 50 mg of diclofenac and 500 mg of paracetamol. Effectively reduces pain and high temperature, eliminates joint stiffness during movement, relieves inflammation. Has a short half-life of components from the body.

It is used orally, daily doses should not exceed 4 tablets, the optimal period of administration is 5 days. It can cause side effects in the form of sensory disturbances, seizures, headaches, sleep disturbances, and even loss of consciousness.

In addition, there may be pain in the stomach, nausea and vomiting, flatulence, and sometimes gastrointestinal bleeding. Excessive doses or prolonged use can also cause anemia, edema, provoke a hypertensive crisis, bronchospasm, acute renal failure.

The drug is contraindicated in children under 14 years of age, people with hypersensitivity to paracetamol and diclofenac, patients with peptic ulcers or impaired kidney and liver function. During the period of taking the drug, it is better to refuse to drive a car or work that requires special care and caution. The treatment of pregnant and lactating women with this drug is strictly prohibited.

Diklak

The German drug (Salutas Pharma GmbH) belongs to the group of antirheumatic, anti-inflammatory, decongestant and analgesics, it has only one active substance - diclofenac as a derivative of phenylacetic acid.

Available as 50 mg enteric tablets, modified release tablets (75 mg, 150 mg) or injection in 3 and 25 mg ampoules. The effect of the drug appears on average 2-3 hours after taking the pill and 10-20 minutes in the case of intramuscular injection.

Significant relief is noted after 1-2 weeks of use of the therapeutic agent in patients with diseases:

• gout;
• rheumatoid arthritis;
• tendinitis;
• periarthritis;
• bursitis;
• joint injuries;
• postoperative pain.

The drug has the same side effects and contraindications as the main group of nonsteroidal anti-inflammatory and antirheumatoid drugs.

diclocaine

Produced in Ukraine by the pharmaceutical company Zdorovye. In addition to diclofenac, it contains lidocaine hydrochloride. Available only in ampoules for injection of 2 ml. It has analgesic, anti-inflammatory and antipyretic effects. The presence of lidocaine significantly reduces pain symptoms at the injection site. It is soaked up at intramuscular application within 10-20 minutes.

It is prescribed strictly according to the prescription for such diseases:

• exacerbation of rheumatism;
• various types of neuralgia;
• arthritis of various origins;
• hepatic and renal colic;
• thrombophlebitis and other diseases accompanied by pain and fever.

Diclocaine relieves pain within 3-5 days, without causing serious side effects, except for individual intolerance to the components of the drug. The drug is contraindicated for children and the elderly. Other contraindications for use include:

• peptic ulcer;
• pregnancy and breastfeeding;
• asthma;
• blood diseases;
• heart and kidney failure.

Diclofenac

Non-steroidal anti-inflammatory drug produced by Hemofarm A.D., Serbia-Russia. The composition includes one active ingredient - diclofenac. It is used to relieve pain in the following branches of medicine:

• surgery;
• gynecology;
• oncology;
• neurology;
• sports medicine;
• traumatology;
• urology;
• ophthalmology.

The medication is presented in two variations:

1. Enteric-coated tablets 50 mg;
2. Tablets with prolonged action in a film shell of 100 mg.

Treatment with the drug is carried out for a limited time. It has been established that long-term use of the drug can cause cardiovascular diseases, up to heart attacks. There are also deviations in the nervous system (drowsiness, dizziness, memory loss, disorientation, mental disorders, etc.). The drug also affects the state of the sense organs. There may be a deterioration in vision, hearing, taste sensations are disturbed.

Dolex

It is produced in India by Twilight Litaka Pharma Limited, belongs to the group of NSAIDs, contains two active substances: paracetamol - 500 mg and diclofenac - 50 mg. Two-layer tablets: white part and orange with splashes. Pharmacological action combines the features of each of the active components included in the composition. Diclofenac contributes to:

• restoration of joint mobility;
• subsidence of pain;
• inhibition of platelet aggregation.

Paracetamol relieves:

• inflammation;
• pain symptoms.

In addition to the typical indications for the use of such analogs, diclofenac is effective in severe migraines, inflammatory diseases of the ears, throat and nose with severe severe pain. The drug is not advised to use for longer than 5-7 days, after which the side effects typical of this drug group increase.

In addition, there have been cases of erosions and ulcers in the gastrointestinal tract, hemorrhagic colitis, bronchospasm, tachycardia, arterial hypertension, anemia, pancreatitis and pneumonia.

The combined preparation of the NSAID group contains active ingredients per 1 tablet:

• paracetamol - 500 mg;
• diclofenac potassium - 50 mg;
• serratiopeptidase - 15 mg.

The authors of the combination from the Indian company J. Duncan Helsker Pvt.Ltd chose just such a proportion of the components to enhance the action of the antipyretic-analgesic with a proteolytic enzyme. Therefore, the drug is effective in combating inflammation, accompanied not only by severe pain, but also by significant swelling and fever.

Maxigezik is used for the rapid relief of acute pain in diseases of the musculoskeletal system, muscle and neuralgic disorders, with toothache and in gynecology. It has the same dosage, timing of use, side effects and contraindications as other NSAID analogues. Full analogues in the composition of active substances are Fanigan, Diklovit and Tilda.

Naklofen Duo

A drug with one active substance - diclofenac sodium. Produced in Slovenia by the international pharmaceutical company Krka, specializing in generic drugs. It is presented in the form of modified release capsules.

1 capsule 75 mg contains the same substance in two forms:

• 25 mg enteric diclofenac;
• 50 mg of a substance with prolonged action.

This provides an increase in the duration of the therapeutic effect and reduces the dose of the drug. The daily dose is not more than 150 mg, the course is 1-2 weeks. Indications for use, side effects and contraindications are the same as for analogues.

A negative effect of the therapeutic agent on fertility was noted, in connection with these women who are planning a pregnancy, the drug is not prescribed. Naklofen Duo is contraindicated in patients with alcoholism.

It should be borne in mind that in infectious diseases, the drug masks their symptoms.

When using the drug, it is impossible to perform work with a high degree of risk, since the speed of physical and mental reactions decreases.

Ukrainian non-steroidal drug with analgesic and anti-inflammatory action. Available in several forms:

• tablets;
• gel;
• ointment;
• injection solution.

The composition includes diclofenac sodium as a basic substance. Auxiliary components are selected in accordance with the release form. Ortofen is indicated in the treatment of inflammatory processes accompanied by severe pain:

Contraindications and side effects are the same as other similar drugs in this group.

Fanigan

Non-steroidal drug from the Indian-Ukrainian manufacturer Kusum Helthker Pvt. Ltd/Kusum Pharm to relieve inflammation, fever and pain. Made on the basis of paracetamol and diclofenac. The active substances inhibit prostaglandins, which are present in all human tissues and organs, and increase sensitivity to pain mediators.

Produced in tablets with prolonged action, which contain 50 mg of diclofenac sodium and 500 mg of paracetamol. It is indicated for the treatment of fevers, inflammations and pains caused by the following conditions:

• arthritis;
• spondylitis;
• gynecological and dental diseases;
• orthopedic edema and trauma.

The combination of active ingredients prevents degeneration of the joints, restores their motor activity, and normalizes thermoregulation. The drug has a number of contraindications:

• children's age up to 14 years;
• intolerance to the main components;
• stomach ulcer;
• proctitis and hemorrhoids;
• internal bleeding;
• problems with the functioning of the kidneys, liver and cardiovascular system;
• congenital hyperbilirubinemia;
• pregnancy planning, gestational period, breastfeeding.

It is often used at bedtime to relieve pain symptoms during the rest and recovery period of the patient.

Dosage does not exceed 3 tablets per day, treatment - 3-7 days. For the elderly, the dose should be reduced.

Flotak

Novartis Pharma AG (Switzerland) produces capsules containing 75 mg of long-acting diclofenac sodium. Dosage, indications for use, overdose symptoms, restrictions and a ban on taking a therapeutic agent are similar to those common in the treatment group. Studies also note the effectiveness of drug therapy in such cases:

• surgical and post-traumatic treatment in ophthalmology;
• migraines of various nature;
• inflammation caused by internal prosthetic devices (implant or graft);
• inflammatory processes in the pelvis.

Performing an antipyretic function, the drug at the same time is not indicated for use in isolated fever. Unlike other analogues, Flotak is well tolerated by children over 6 years of age.

Substitutes based on ketorolac

Among non-steroidal agents aimed at relieving inflammation and developed on the basis of acetic acid derivatives, one can single out funds with ketorolac. The action of this substance is as close as possible to diclofenac.

Ketanov

An effective non-narcotic analgesic manufactured by the Indian company Ranbaxi Laboratories Limited. It is used to relieve pain syndromes of moderate and severe severity of various origins. It also has anti-inflammatory properties and moderately lowers fever, while it does not depress breathing, does not affect receptors, does not cause dependence and sedative action, and is comparable to morphine in terms of the effectiveness of pain relief. It is used once and in treatment courses of 5-7 days.

As an active substance, unlike Neurodiclovit, this drug uses another derivative of acetic acid, which also belongs to the group of non-steroidal anti-inflammatory drugs - ketorolac tromethamine.

Available in two forms:

1. Tablets (10 mg) with a characteristic engraved brand name "KVT" on one side.
2. Solution for intramuscular injections of a slightly yellowish color (1 ml ampoules).

Application is contraindicated in the following cases:

• hypersensitivity to components;
• asthmatic manifestations;
• ulcers;
• hemophilia;
• renal and liver failure;
• strokes;
• bleeding;
• the period of pregnancy and breastfeeding;
• children under 16 years of age.

Ketorolac

Ketorolac is produced in Russia and Belarus in the form of tablets, as well as a solution for intramuscular and intravenous administration. The active component of ketorolac tromethamine helps to relieve pain and inflammation, thereby lowering the temperature caused by inflammatory processes. Particularly effective in postoperative therapy.

Doses are selected in proportion to the intensity of pain manifestations within 15-30 mg every 4-6 hours, the course of treatment is no more than 5 days. An overdose can lead to ulcerative lesions of the gastrointestinal tract, interruptions in the functioning of the kidneys, and loss of consciousness.

Neurodiclovit and its analogues quickly and effectively eliminate pain in diseases of the musculoskeletal system. Neurodiclovit is a combination drug from the Austrian company Gerot Lannach Pharma. The drug consists of diclofenac sodium and B vitamins.

For example, with osteochondrosis of the spine, which affects more than half of humanity, there may be a sharp pain in the back. Because of it, a person literally freezes in one position, since an attempt to make any movement will only increase the pain. This condition is the result of compression of the spinal nerves. This is the result of degenerative cartilage damage and reactive changes occurring in the vertebrae.

What are Neurodiclovit and its analogues used for?

Neurodiclovit is convenient to use, as it saves the patient from taking a number of drugs and reduces the duration of treatment. The results of studies have shown that when using vitamins B with diclofenac, the pain goes away faster. And since diclofenac has many side effects, it is preferable to take a shorter course of treatment with this medicine. In this case, this drug is the most suitable remedy that copes with disorders of the musculoskeletal system and the nervous system.

Diseases for which this drug is indicated:

• neuralgia;
• neuritis;
• polyarthritis;
• sciatica;
• arthritis (of various origins);
• arthrosis;
• lumbago;
• osteochondrosis (cervical, thoracic, lumbosacral).

The drug is also used with an increase in temperature, the formation of edema and swelling.

Each capsule contains:

• diclofenac (50 mg) - active ingredient;
• vitamin B1 (thiamine hydrochloride);
• vitamin B6 (pyridoxine hydrochloride);
• vitamin B12 (cyanocobalamin);
• auxiliary components.

Similar drugs

There are no analogues, which would simultaneously include vitamins of group B and NSAIDs. Therefore, if necessary, the most suitable substitutes are selected.

Similar drugs, the trade names of which sound different, but their main substance is the same, with which Neurodiclovit can be replaced:

• Bioran;
• Voltaren;
• Voltaren Akti;
• Voltaren Rapid - powder, a suspension is prepared from it;
• Diklak;
• Diclovit;
• Diclogen;
• Dicloran;
• Dicloran SR;
• Diclofenac;
• Diclofenac Bufus - solution for injection;
• Diclofenac Retard - long-acting tablets;
• Dolomin;
• Naklofen;
• Naklofen Duo - modified release capsules;
• Naklofen SR - long-acting tablets;
• Naklofen Protect;
• Ortofen;
• Panoxen;
• Rapten Duo;
• Rapten Rapid;
• Swiss Jet Duo;
• Tabuk Dee;
• Flotak;
• Movalis;
• Meloxicam;
• Ketorolac;
• Lornoxicam.

In various preparations, the dose of diclofenac is different, therefore, when selecting an analogue, this fact must be taken into account. Since each drug has its own specifics and contraindications, a doctor's consultation is required.

Treatment with Neurodiclovitis is often continued with Neuromultivit. This drug contains similar vitamins, but without diclofenac. Neuromultivit is prescribed for the treatment of neurological diseases. When the question arises of replacing Neurodiclovit, the fact of the presence of neuritis is taken into account. If such therapy is necessary, Neuromultivit can be used instead of Neurodiclovit.

1. Thiamine (B1) - is involved in metabolic processes and the transport of nerve impulses.
2. Pyridoskin (B6) - is found in substances responsible for the functioning of the nervous system. These include dopamine, adrenaline, serotonin, histamine. All of them ensure the normal state of the nervous tissue.
3. Cyanocobalamin (B 12) - has a positive effect on the blood, in particular on the formation of red blood cells in the bone marrow, promotes the renewal of nerve cells.

In complex treatment, these vitamins enhance the properties of diclofenac. Due to this, this combination of drugs quickly relieves pain of a neuralgic nature.

Who is assigned

Also indications for use are:

1. Post-traumatic pain.
2. The rehabilitation period after the operation.
3. Dental treatment.
4. Gynecological pain, not having an infectious nature.
5. Respiratory diseases.

All nonsteroidal drugs have side effects, and diclofenac is no exception.

Possible adverse reactions

Digestive system:

• flatulence and abdominal pain;
• stool disorder - diarrhea or constipation;
• nausea and urge to vomit;
• overloaded liver;
• jaundice.

From the side of the nervous system, the following side effects are possible:

• headache and dizziness;
• insomnia or increased sleepiness;
• increased nervous excitability;
• depression and stress;
• increased sense of fear;
• lack of coordination;
• muscle cramps.

Sense organs:

• extraneous noise in the ears;
• blurred vision;
• change in taste;
• hearing impairment (serious attention should be paid to this, since after discontinuation of the drug this phenomenon can become chronic).

• the appearance of itching;
• allergic rash, urticaria;
• hair loss;
• eczema.

Urogenital system:

• deterioration of kidney function;
• the appearance of edema;
• excretion of protein in the urine;
• reduction in the amount of urine excreted;
• the appearance of blood in urine;
• decreased libido.

Complications from chronic diseases are possible.

Respiratory system:

• the appearance of a cough;
• spasms from the bronchi;
• pneumonia;
• swelling of the larynx.

Contraindications for use

• hypersensitivity to any of the components contained in the preparation;
• hypersensitivity to any nonsteroidal drug;
• exacerbation of gastrointestinal diseases;
• bleeding (any);
• asthmatic cough;
• hematopoietic disorders (poor clotting);
• pathology of the kidneys or liver;
• heart problems;
• after open heart surgery;
• high levels of potassium in the blood;
• pregnancy;
• children's age and adolescents under 18;
• acceptance of alcoholic beverages;
• diabetes.

Price difference

Often, when doctors prescribe medications to a patient, the question arises of replacing drugs with more affordable ones. Many people think that Russian analogues are cheaper because they are not subject to additional import duties.

The price of similar drugs manufactured by different companies can differ tenfold. And the buyer has a natural question, if the active substance is the same, then why such a difference in cost.

The manufacturer spends a lot of money on the original drug - research, advertising, etc. Therefore, the manufacturer tries to compensate for the losses by selling the drug at a high price. And generics are no longer being researched and produced using the same technology, but under a different name.

The next aspect that significantly increases the price is the packaging. The more beautiful and better it is, the higher the price. But this does not affect the quality of the medicine. As for the choice between a domestic product and an imported one, it is known that foreign analogues are produced using higher technologies, therefore the quality of such drugs is much higher.