Furazolidone dosage. Furazolidone for the treatment of intestinal infections in children of different ages: effectiveness and instructions for use

And the genitourinary system, giardiasis. The medicine is often used in pediatrics, since it has a gentle effect on the body.

Composition, release form, packaging

The main active ingredient is furazolidone(50 mg).

Additional:

• calcium stearate;
• sucrose;
• potato starch;
• polysorbate Twin-80;
• lactose.

Produced in flat-cylindrical tablets in contour cell and non-cell packs of 10, 20, 25 pieces, packed in cardboard boxes.

Pharmacological properties

Antimicrobial and antiprotozoal agent. It has a bacteriostatic effect on microbes.

Action spectrum:

• gram-positive and gram-negative bacteria (most active against and shigella);
• Trichomonas.

Indications for use

What does Furazolidone treat, and in what cases are these tablets given to children:

• giardiasis;
• trichomoniasis;
• amoebiasis, amoebic dysentery;
• bacterial colitis with loose stools.

At what age can children

"Furazolidone" in tablets can be given to children as soon as they reach. But not before!

Method of application and dosing regimen

Dosage and number of doses for other disorders selects a pediatrician. The type of deviation, degree of severity, age and child are taken into account.
The norm per day is 10 mg per 1 kg of weight. As a rule, a portion of the medicine for children is divided into 3-4 times. That is, a baby weighing 20 kg needs 200 mg of Furazolidone per day - 4 tablets (1 pill four times a day). It is impossible to continue treatment for more than 10 days.

special instructions

In order to avoid side effects, children are recommended to take "Furazolidone" together with a special diet when you can not eat food rich in tyramine: cheese, chocolate, smoked meats, spices, etc. Diuretic drink, such as a decoction of lingonberries, favorably affects the course of treatment.

Contraindications and side effects

Absolute contraindications:

• age ;
• kidney failure;
• hypersensitivity to the drug.

• deficiency of the enzyme glucose-6-phosphate dehydrogenase, lactose intolerance;
• disorders of the nervous system;
• liver pathology.

Of course, how many people, so many opinions, but, based on the many responses, the undesirable effects of the drug are quite rare, since Furazolidone is low-toxic. However, it happens that side effects still arise. And before giving the remedy to children, you need to familiarize yourself with these effects:

• loss of appetite;
• abdominal pain;
• nausea, vomiting;

Important! How to drink "Furazolidone"- described in detail in the instructions for use. It is recommended to give it to children after taking it along with plenty of water. Do not crush or chew the tablet.

What to replace

According to the active substance, there is no similarity to "Furazolidone". True, there are medicines with a different composition, but with a similar effect. Therefore, it is often replaced by analogues:

1. - is prescribed for diarrhea, intestinal infections, giardiasis, food poisoning. The active substance is nifuroxazide. The degree of its purification is higher, but the product is also more expensive.
2. "Nifuroxazide" is a synthetic drug that relieves indigestion caused by a bacterial infection.
3. "Gepar compositum" - stimulates the hepatotoxic function of the liver, is a choleretic, antioxidant agent.
4. "Norbactin" is an antibiotic for the treatment of infections caused by microorganisms sensitive to the active substance (norfloxacin).

"Furazolidone" is a fairly popular drug. But before taking it, you need to consult a pediatrician to find out if it is right for your child to give it. Also remember to follow the instructions and calculate the dosage correctly. In this case, the medicine will only benefit your baby.

Children, especially at a younger age, are very susceptible to various infections, including intestinal ones. This is due to the fact that some factors, such as poor-quality food, medication, and others, against the background of an immature immune system, can provoke the development of the disease. Diseases of the gastrointestinal tract must be dealt with. Very often, the drug Furazolidone comes to the rescue. How effective is it for treating children and is it safe for young patients?

The action and effectiveness of the drug

Furazolidone is a drug from the group of nitrofurans that has antimicrobial activity. It has the greatest effect on gram-positive bacteria that cause infections of the gastrointestinal tract such as salmonellosis, dysentery, food poisoning, that is, food poisoning of poor quality.

Furazolidone is not very effective against pathogens of purulent diseases, therefore, it is practically not used for their treatment.

The main feature of Furazolidone is that the addiction of bacteria to it develops very slowly. This is the reason for its high efficiency. However, most often the remedy is prescribed in combination with other antibacterial drugs. Once in the intestine, the drug is rapidly absorbed and dispersed through the tissues, then decomposed in the liver into metabolic products and excreted in the urine or feces.

Composition and dosage forms

Furazolidone is available in the form of tablets and granules for the preparation of a suspension for oral administration.

Furazolidone is an antibacterial drug recommended for the treatment of gastrointestinal infections.

The drug in the form of a suspension is allowed to be given to children according to indications after the first month of life. Tablets are contraindicated up to 3 years. The release forms also differ in the concentration of the active substance: in the granules, the content of furazolidone is lower. In addition, the composition of the drug includes the following auxiliary components:

• calcium stearate;
• polysorbate;
• sucrose;
• lactose;
• potato starch.

Indications for use

Furazolidone is effective in infectious diseases of the gastrointestinal system. A pediatrician may prescribe a drug to a child in the following cases:

• food poisoning (poisoning);
• dysentery;
• giardiasis;
• cholera;
• paratyphoid;
• rotavirus infection.

In addition, the drug is used in the treatment of trichomonas colpitis and urethritis, as well as for the healing of infected burns and wounds.

Furazolidone is used for the symptomatic treatment of diarrhea in children from a very early age.

Contraindications, side effects and interactions with other drugs

According to the instructions, Furazolidone has the following contraindications:

• hypersensitivity or individual intolerance to the components of the drug;
• severe liver failure;
• kidney disease with impaired function;
• diseases of the nervous system;

Many parents are interested in the safety of the drug for the child's body. The negative effect of Furazolidone is very rare, and the effectiveness is quite high. Side effects may be as follows:

• allergic reactions, which are manifested by rashes, redness and itching of the skin;
• nausea and vomiting;
• decreased appetite.

In case of an overdose, the risk of developing complications of existing pathologies increases. Also, an excess of the drug can provoke toxic liver disorders (acute toxic hepatitis) and some nervous diseases of the extremities (polyneuritis).

If the baby has received a large dose of the drug, it is urgent to consult a doctor. Gastric lavage is usually prescribed, in especially severe cases, hemodialysis is required - a method of blood purification using an "artificial kidney" apparatus.

Furazolidone is forbidden to be taken together with antidepressants and drugs containing ethanol, amphetamine, ephedrine, phenylephrine.

Instructions for use

For children, Furazolidone is recommended in the form of granules for the preparation of a suspension. Before use, it is necessary to pour boiled water into the vial with the substance up to the indicated mark and dissolve the contents. Shake the bottle before each use.

The dosage regimen is determined solely by the pediatrician. The doctor is based on the individual indicators of the baby - his age and weight, diagnosis and nature of the course of the disease. The duration of the course of treatment is from 5 to 10 days. Furazolidone is taken 4 times a day after meals.

What can replace Furazolidone for children

If an allergic reaction occurs or the drug is ineffective, the doctor may prescribe another drug with a similar pharmacological effect to the baby.

Substitute drugs - table

Content

Among the derivatives of the nitrofuran series is the antibacterial drug Furazolidone (Furazolidone), which is prescribed for protozoal invasion of the digestive tract and skin, genitourinary diseases of bacterial etiology. A drug with a pronounced bacteriostatic effect is active against various microbes.

Composition and form of release

The medical preparation Furazolidone is produced in the form of yellow flat-cylindrical tablets of 10 pcs. on a blister. Each package contains from 2 to 5 blisters, instructions for use are attached. More tablets are packed in jars of polymeric material, 50 pcs. The second form of release, more intended for the treatment of infections in children, is granules for the preparation of a suspension of 50 or 100 g, in 150 ml glass jars with a measuring cup. The chemical composition of the drug:

Furazolidone is an antibiotic or not

It is an antimicrobial drug of the nitrofuran group. The active substance of the same name belongs to the synthetic class of antibacterial agents, it acts in a complex way. The drug is active against Gram-positive and Gram-negative bacteria, Trichomonas, Giardia, Salmonella, pathogenic fungi, Shigella, Campylobacter, Vibrio cholerae. Does not affect anaerobes and Pseudomonas aeruginosa.

Indications for use

• cholera;
• dysentery;
• enterocolitis;
• traveler's diarrhea;
• food poisoning;
• cystitis;
• trichomonas colpitis;
• urethritis;
• pyelitis;
• paratyphoid, typhus;
• giardiasis, shigellosis, salmonellosis;
• infected burns and wounds.

Method of application and dosage

Furazolidone is intended for oral administration. The tablet must be swallowed whole, not chewed, washed down with a sufficient amount of water. The recommended course of treatment and daily doses depend on the nature and stage of the pathological process:

Furazolidone for children

• from 1 to 12 months: 10 mg per 1 kg of weight for 3 days, then take a three-day break and repeat the treatment;
• from 1 to 8 years: the maximum dosage is 0.15 g, the course of treatment is no more than 10 days.
• children over 8 years old: the daily dose is 5 mg per 1 kg, which is required to be divided into 3-4 doses.

It is recommended to first dilute the drug in the form of granules for the preparation of a suspension with boiled water, mix well until the precipitate is completely dissolved. After taking orally, according to the instructions. Furazolidone tablets are contraindicated for children under 3 years of age.

With cystitis

Furazolidone destroys the pathogenic intestinal flora, which provoked an exacerbation of inflammatory processes in the genitourinary system and bladder. To exterminate urogenital infections, you need to choose the right daily dosage:

• children from 1 year: 10 mg per 1 kg of body weight, divide the dose received into 3 doses. The course of treatment is 3 days, after a three-day break, and the treatment is resumed.
• adults: 2 tablets. 4 doses per day, the course of treatment varies from 3 to 7 days.

Furazolidone for diarrhea

With diarrhea, Furazolidone tablets are prescribed after meals, it is recommended to drink plenty of water. The course of treatment should not exceed 10 days, but the positive dynamics is noticeable already on the 3rd-5th day of home therapy. Daily doses depend on the age of the patient:

• Furazolidone for children from 1 year: 10 mg per 1 kg of body weight of the child, the resulting dose is divided into 3 doses;
• patients from 5 years old: 0.5–1 tab. four times a day;
• adults: 2-3 tablets. three times a day.

special instructions

When treating with Furazolidone, it is recommended to temporarily refuse or reduce daily portions of cottage cheese, cream, butter, hard cheese, strong tea, coffee. For the prevention of polyneuritis, it is additionally required to include in the diet products with B vitamins, multivitamin complexes. The drug does not depress the functions of the nervous system, does not inhibit the psychomotor reactions of the body. Furazolidone for children under one year is prescribed for health reasons.

Furazolidone during pregnancy

The studied medication during gestation and lactation is prescribed with caution. Furazolidone tablets are not recommended in the first trimester of pregnancy, in the rest of the obstetric period - for health reasons. If there is a possibility of giving birth to a child with a deficiency of glucose-6-phosphate dehydrogenase, after the use of Furazolidone there is a risk of developing hemolytic anemia. During lactation, it is required to urgently raise the question of a temporary cessation of breastfeeding.

Application in veterinary medicine

The veterinary drug is somewhat different, it is a water-insoluble yellow powder. Furazolidone is used for salmonellosis, coccidiosis, colibacillosis, enteritis, balantidiasis in animals and birds. The course of treatment is 10 days, it is important to avoid cases of overdose. The daily dose for the treatment of chickens, turkeys, broilers is 3 mg per head twice a day for 8 days. If necessary, treatment is resumed after a 10-day break.

drug interaction

Furazolidone must not be combined with alcohol-containing drugs, since the risk of toxic effects on the liver increases (disulfiram-like reactions develop), and the nervous system is depressed. Other information about drug interactions is described in the instructions for use:

1. The simultaneous use of the drug with antacids, magnesium, aluminum and iron preparations is prohibited, since the absorption of Furazolidone and its therapeutic effect are reduced.
2. In combination with Tetracycline, aminoglycosides, the antimicrobial effect of both drugs is enhanced, therefore, additional correction of daily dosages is required.
3. Antidepressants, MAO inhibitors, Phenylephrine, Ephedrine, Tyramine, Amphetamine contribute to an increase in blood pressure during the use of Furazolidone.
4. With simultaneous use with Chloramphenicol and Ristomycin, the work of the hematopoietic organs is disrupted (blood clotting decreases).

Side effects

The drug is well tolerated by the body. Infrequently there are such side effects:

• loss of appetite, nausea, signs of dyspepsia, vomiting, anorexia, bloating, cholestatic jaundice;
• skin rash, urticaria, skin itching, redness and swelling of the dermis, angioedema, dermatitis;
• shortness of breath, pulmonary edema, dry cough, bronchospasm (with prolonged use), asthma attacks;
• aggression, irritability, tremor of the limbs, insomnia, dizziness, migraine attacks, polyneuropathy;
• chills, fever, arthralgia, myalgia, convulsive syndrome;
• thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, megaloblastic anemia.
• with prolonged use: neuritis, hepatotoxic effect;
• peripheral neuropathy (in diabetes mellitus, hypovitaminosis B and C, anemia).

Overdose

In case of systematic excess of daily doses, toxic hepatitis, polyneuritis develops, blood clotting is disturbed. The first step is to stop further taking Furazolidone, then the doctor prescribes antihistamines and B vitamins, drinking plenty of fluids.

Contraindications

The drug is not prescribed for hypersensitivity of the body to active substances, during pregnancy, lactation, renal and hepatic insufficiency. Tablets are not recommended for children under 3 years of age, suspension - for patients under 1 month of age.

Terms of sale and storage

The medicine is sold without a prescription. Store the medication in a dry, cool and dark place out of the reach of small children. The shelf life is 3 years.

Analogues

In the event of side effects or in the presence of medical contraindications, Furazolidone is not prescribed. Analogues of the drug and their brief characteristics:

1. Nifuroxazide. Yellow tablets have a bactericidal and antibacterial effect, recommended for use in adult patients. Children are prescribed a sweet suspension with a fruity taste. The drug is good for diarrhea of ​​various origins.
2. Rifaximin. A drug with an identical principle of action in the body. It has 2 dosage forms - tablets and suspension for oral administration. It is important to avoid cases of overdose.
3. Imipenem. It is a bactericidal, antibacterial, antimicrobial agent recommended for infections of the genitourinary system, abdominal organs, and respiratory tract.
4. Azithromycin. These are tablets, capsules and powder with an antibacterial effect. This semi-synthetic antibiotic, effective for the extermination of gram-positive, gram-negative bacteria, protozoa, strains.
5. Amikacin. The drug is released only in the form of a white powder for the preparation of an injection solution (intramuscularly, intravenously). There is no tablet form of release of Amikacin.
6. Ciprofloxacin. These are ear and eye drops, tablets, an infusion solution with a pronounced bactericidal effect, is an early fluoroquinolone. The drug is an antibiotic, evenly distributed in tissues.

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Children under 4 years of age are especially susceptible to intestinal infections, since they have not yet developed strong immunity. The child's body cannot fully produce antibodies to microbes, which leads to intoxication of the entire digestive system. To eliminate the infection, use "Furazolidone". This effective, but still toxic drug is given to babies strictly according to the doctor's prescription.

The principle of operation of the drug Furazolidone

"Furazolidone" is an antimicrobial and antiprotozoal agent from the Nitrofuran group, prescribed to children mainly to fight intestinal infections. Unlike other drugs, "Furazolidone" not only eliminates the pathogenic flora, but also strengthens local immunity, stimulates the body's independent fight against infection.

Accustoming to "Furazolidone" develops slowly. The drug is effective against:

The drug in a minimal amount quickly enters the bloodstream through the gastrointestinal tract. Active components are stored in the blood for 8 hours after taking the drug. The drug destroys the shell and respiratory apparatus of microorganisms, preventing their reproduction. The child's well-being improves from the first days of treatment.

"Furazolidone" does not accumulate in the body, but is metabolized in the liver, due to which it is prescribed to babies. In some cases, the amount of the drug in the intestine exceeds the norm, which does not pose a danger to the child. Inactive chemical compounds and furazolidone unchanged are rapidly excreted through the kidneys.

Forms of release of the drug

"Furazolidone" has 2 pharmacological forms:

1. Yellow flat-cylindrical tablets. Each tablet contains 50 mg furazolidone. The drug is available in blisters of 10 tablets each. The package contains up to 5 plates. Also, the medicine is sold in plastic jars of 50 tablets each. Designed for children over 3 years of age.
2. Granules. Yellow and green particles have a lower concentration of the active substance than the previous form. Used to prepare a suspension for the treatment of children from 1 year. The package contains a plastic bottle with 50 g of granules and a measuring spoon.

When is it applied?

According to the instructions, the use of "Furazolidone" is indicated for:

Dosage and method of application

The dose of "Furazolidone" is determined by the doctor based on the age of the patient and the degree of the disease. Subject to the dosage, the drug does not affect the functioning of the central nervous system and does not slow down the rate of psychomotor reactions. Sometimes taking the medicine leads to the development of polyneuritis - loss of sensitivity of peripheral nerves. In order to avoid complications, "Furazolidone" is prescribed for children together with vitamin B.

Tablets

Tablets are used topically and orally. In the first case, the medication is used from the first month of a baby's life to prepare solutions for lotions that are applied to wounds. For internal use, the daily dose is calculated based on the proportion of 10 mg of the drug / per 1 kg of the child's weight, dividing it into 4 doses. The medicine is taken after a meal.

The therapeutic effect is observed 2 days after the start of treatment with Furazolidone. As a rule, the duration of therapy does not exceed 10 days, but in some cases the doctor may increase it. If within a week after the start of therapy the baby's condition does not normalize, it means that the causative agent of the pathology is immune to the drug. In this case, you need to choose another medicine.

Granules for suspension preparation

To prepare the suspension, you need to pour boiled water into the bottle with granules up to the 100 ml mark. The liquid is taken in the same mode as the tablets, but in a different dosage. Babies under 2 years old are given 5 ml of medication, increasing the dosage by 1 ml every year. After shaking, the suspension is taken after meals.

Regardless of the form of medication used, the child's nutrition should be limited during the treatment period. It is necessary to exclude foods rich in tyramine from the diet: fatty broths, hard cheese, herring, liver, smoked meats, stew, chocolate, strong tea and coffee. Treatment of infectious pathologies of the gastrointestinal tract is accompanied by intestinal upset, which can be avoided with the help of drugs with enzymes and probiotics.

Therapy is continued for as many days as the doctor has established. There is no need to stop taking the medicine, even if the child gets better. The disappearance of symptoms of intoxication does not indicate the complete elimination of the pathogenic flora that provoked it. Premature withdrawal of the drug leads to the resumption of infection with greater force.

How safe is the drug for children?

Safety is the determining criterion for choosing a drug for the treatment of gastrointestinal disorders in children in the first months of life.

The high performance of "Furazolidone" is combined with a low likelihood of side effects. Complications are associated with overdose and taking the drug in the presence of contraindications.

Side effects

• nausea and vomiting;
• loss of appetite;
• diarrhea;
• dizziness and headache;
• weakness and reduced activity;
• drowsiness;
• irritability;
• local allergic reactions - rash and itching of the skin.

If mild side effects occur, you can divide the daily dose of the drug into 5-6 doses. It must be remembered that Furazolidone is toxic, and therefore it must be taken after meals. It is better to drink the medicine together with sorbents: activated carbon, Smekta, Sorbeks. To prevent the onset of allergies, the baby is given antihistamines.

Overdose

"Furazolidone", used to eliminate intoxication, if used incorrectly, leads to severe drug poisoning. In such cases, the worsening of the course of the underlying pathology is most often noted, but it also develops:

• shortness of breath and cough;
• convulsions;
• pain in the epigastric region;
• hyperthermia;
• liver intoxication;
• polyneuritis;
• excess and decrease in hemoglobin in the blood, which is especially dangerous for a one-year-old baby.

If there are signs of an overdose, you should immediately consult a doctor. Due to the lack of an antidote to Furazolidone, these symptoms are eliminated by gastric lavage, taking sorbents and laxatives. In severe drug poisoning, restoration of water and electrolyte balance is indicated.

Contraindications

"Furazolidone" is a toxic drug and can worsen the course of some somatic diseases.

It is unacceptable to take the medicine in the presence of the following contraindications:

• hypersensitivity of the patient to the components of the drug;
• severe pathologies of the liver and kidneys;
• neurological disorders;
• lactase deficiency and lack of glucose-6-phosphate dehydrogenase;
• up to one year of age.

Interaction with other drugs

Giving children "Furazolidone", you need to remember about its ability to react with individual drugs. In order to avoid sudden jumps in blood pressure, this medication is not prescribed with antidepressants and vasoconstrictors. The combination of "Furazolidone" with the antibiotics "Ristomycin" and "Chloramphenicol" provokes circulatory disorders.

Hello! The child is 4 and a half years old, weight 18 kg, height 118 cm. In the morning loose stools, almost every half an hour. How and how much can you drink Furazolidone?

Expert answer

Moshovis_Anna Family doctor

Good evening!

First of all, which is especially important for children, you need to know the exact cause of diarrhea. It can be caused by dietary habits, stress, and yes, bacterial agents. Which are also diverse and are treated, respectively, in different ways.

Furazolidone is used to treat dysentery, giardiasis, food poisoning, paratyphoid, typhoid fever and to destroy some other microorganisms that are sensitive to the action of the drug.

For children, the drug is prescribed at a dose of 10 mg per kg of body weight. That is, 180 mg is the daily dose for your child. We divide the dose into 3-4 doses. 1 tablet - 50 mg.

The drug is taken no more than 10 days. It is difficult to say how many days in your case, since the cause of diarrhea is not clear. Therefore, I strongly recommend that you contact the district pediatrician, who will prescribe the necessary examination and adjust the treatment. You may need to consult an infectious disease specialist.

Get well!

!

Consultation on the topic "How much to give Furazolidone to a child from diarrhea?" is given for reference purposes only. Based on the results of the consultation, please consult a doctor, including to identify possible contraindications.