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Polydex Solutab instructions for use. Unidox Solutab - instructions for use

YAMANOUCHI EUROPE B.V. / ORTAT (KOSTROMA YAMANOUCHI EUROPE BV / ORTAT (Kostroma) Astellas Pharma Europe B.V. Astellas Pharma Europe B.V./Ortat CJSC ZiO-Zdorovye, CJSC Yamanuchi Europe B.V. Yamanuchi Europe B.V./ "ORTAT" Company

Country of origin

Netherlands Netherlands/Russia Russia

Product group

Antibacterial drugs

Antibiotic of the tetracycline group

Release form

Tablets 100 mg - 10 pcs.

Description of the dosage form

Dispersible tablets

pharmachologic effect

Antibiotic - tetracycline. It acts bacteriostatically, inhibits protein synthesis in a microbial cell by interacting with the 30S subunit of ribosomes. Active against gram-positive and gram-negative bacteria: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including Enterobacter aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp. (including Rickettsia prowazekii), Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes; some protozoa: Entamoeba spp., Plasmodium falciparum. As a rule, it is not active against Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp. The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-group within a group (i.e. strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics

Absorption Absorption is fast and high (about 100%). Eating slightly affects the absorption of the drug. Cmax of doxycycline in plasma (2.6-3 μg / ml) is achieved 2 hours after taking 200 mg, after 24 hours the concentration of the active substance in the blood plasma decreases to 1.5 μg / ml. After taking 200 mg on the first day of treatment and 100 mg / day on the following days, the concentration of doxycycline in the blood plasma is 1.5-3 μg / ml. Distribution Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into tissues, poorly - into the cerebrospinal fluid (10-20% of the plasma concentration), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane. Vd - 1.58 l / kg. 30-45 minutes after ingestion, doxycycline is found at therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate, eye tissues, in pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluid. With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma. In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined. Doxycycline crosses the placental barrier and is secreted in small amounts into breast milk. Accumulates in dentin and bone tissue. Metabolism Only a small part of doxycycline is metabolized. Excretion T1 / 2 after a single oral intake is 16-18 hours, after taking repeated doses - 22-23 hours. Approximately 40% of the dose taken is excreted in a biologically active form by tubular secretion in the kidneys, 20-40% is excreted through the intestines in the form of inactive forms (chelates). Pharmacokinetics in special clinical cases T1 / 2 doxycycline in patients with impaired renal function does not change, because. its excretion through the intestine increases. Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in plasma.

Special conditions

There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs. Tetracyclines can increase prothrombin time, the use of tetracyclines in patients with coagulopathy should be carefully monitored. The antianabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal kidney function. However, in patients with renal insufficiency, there may be an increase in azotemia. The use of tetracyclines in patients with impaired renal function requires medical supervision. With prolonged use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required. In connection with the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it. Prolonged use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins). To prevent dyspeptic phenomena, it is recommended to take the drug during meals. Impact on the ability to drive vehicles and control mechanisms Features of the impact on the ability to drive a car and control mechanisms have not been studied.

Composition

doxycycline monohydrate, in terms of doxycycline 100 mg Excipients: microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate.

Unidox Solutab indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - respiratory tract infections (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema); - infections of ENT organs (including otitis media, sinusitis, tonsillitis); - infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingo-oophoritis / as part of combination therapy /); - sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea / as an alternative therapy /, inguinal granuloma, venereal lymphogranuloma); - infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);

Unidox Solutab contraindications

- severe violations of the liver and / or kidneys; - porphyria; - pregnancy; - lactation period (breastfeeding); - children's age up to 8 years; - hypersensitivity to antibiotics of the tetracycline group.

Unidox Solutab dosage

100 mg 100 mg

Unidox Solutab side effects

From the digestive system: anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis, esophagitis, esophageal ulcer, dark staining of the tongue, liver damage (during long-term use or in patients with renal or hepatic insufficiency), cholestasis. Dermatological reactions: photosensitivity, maculopapular and erythematous rash, exfoliative dermatitis. Allergic reactions: urticaria, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, pericarditis, a syndrome similar to serum sickness, erythema multiforme. From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity. On the part of the endocrine system: in patients who have received doxycycline for a long time, reversible dark brown staining of the thyroid tissue is possible. From the side of the central nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, swelling of the optic nerve), vestibular disorders (dizziness or unsteadiness), blurred vision, double vision. From the urinary system: an increase in residual urea nitrogen (due to the antianabolic effect). From the musculoskeletal system: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (irreversibly changes the color of the teeth, enamel hypoplasia develops).

drug interaction

Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by a 3-hour interval. In connection with the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants. When doxycilin is combined with bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins), the effectiveness of the latter decreases. Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives. Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin, accelerating the metabolism of doxycycline, reduce its concentration in blood plasma. The simultaneous use of doxycycline and retinol increases intracranial pressure.

Storage conditions

keep away from children

Information provided

Unidox Solutab is effective tool antibacterial properties. The drug is actively used in the treatment of urological, infectious diseases, skin diseases, venereal and ENT organs, inflammation of the pelvic organs.

Today, this highly effective drug has become an innovative drug that belongs to a completely new generation of antibiotics: you can take your medicine in three different types- in the form of tablets, dissolving this tablet in water or in the form of syrup. According to the manufacturers themselves, this is a "patient-friendly" drug, with a high degree of bioavailability and effectiveness.

In the production process of the product, substances such as sodium, gluten and sugar are not used, which allows people suffering from hypertension and diabetes to take the medicine.

Such a non-standard composition of the drug makes it innovative in the consumer market.

You can not use an antibiotic along with alcohol, as the drug enhances the effect of alcohols on the body, which negatively affects the liver.

The drug belongs to the group of tetracyclines, long-term and broad-spectrum. In any pharmacy you can buy Unidox Solutab for 350 rubles. Instructions for use also include a description of the release form of the product: tablets, with the active substance doxycycline monohydrate, auxiliary components.

The tablet has an active effect in the body, destroying entire colonies of harmful bacteria: gram-positive and gram-negative, gonorrheal microorganisms, chlamydia, plasmodium, etc.

The pharmacological action of the drug lies in its active action on different groups of microorganisms and their strains.

All components of the drug are absorbed very quickly and reach a high concentration after 2 hours if 200 mg of the drug was taken.

note

The human body may acquire resistance to the active substance doxycycline and the effectiveness of the drug will decrease.

Therefore, so that strains of pathogens cannot develop resistance to the antibiotic, and the medicinal effect does not decrease, the treatment regimen should not be violated and the recommended dosage of the drug should not be exceeded.

The drug is indicated for the treatment of diseases such as:

Infectious diseases of the respiratory tract (acute bronchitis, tracheitis, community-acquired and lobar pneumonia, lung abscesses, etc.).
Diseases of the ENT organs (tonsillitis, sinusitis, etc.).
Diseases of the genitourinary system (urology, venereology, female infectious diseases).
Sexually transmitted sexually transmitted diseases (syphilis, chlamydia, gonorrhea, etc.).
Infection gastrointestinal tract(cholecystitis, cholera, travelers' diarrhea, cholangitis, etc.).
Infections of soft tissues and skin, acne.
Eye infections.
Prostatitis and ureaplasmosis.
Other infectious diseases.

There are certain restrictions in taking Unidox Solutab, the instructions for use allow it to be used for the prevention of infectious diseases, postoperative complications, expressed in the form of the development of purulent manifestations.

However, like any other antibiotic, Unidox Solutab has its own contraindications for use:

Not recommended for severe forms of kidney and liver disease.
Pregnancy and lactation.
With porphyria.
Children up to 8 years old.
In the presence of individual intolerance to the components of the drug.

During pregnancy, the drug is not used in the first and third trimesters, because. the antibiotic can disrupt the development of bone tissue in the fetus, harms the formation of teeth.

If during lactation there is still a need to take the drug, then breast-feeding the baby is stopped so that doxycycline does not enter the baby's body along with the mother's milk.

allergic reactions;
disorders of the gastrointestinal tract;
anemia;
liver damage;
nausea, vomiting;
increased intracranial pressure;
headache;
candidiasis;
increased sensitivity to ultraviolet rays;
vestibular disorders.

If an overdose of the drug occurs, it is urgent to wash the stomach, induce vomiting, take activated charcoal, laxatives. In the case of a severe form of overdose, hospitalization is necessary, during which a specialist doctor will carry out the necessary clinical actions.

Reviews of doctors who used the remedy for the treatment of gynecological infectious diseases, urology and other diseases are quite positive. Any harmful microorganism is amenable to the action of an antibiotic in the shortest possible time. Patients note the ease of tolerance of the antibiotic, the convenience of taking the drug (suspension, tablet), the brevity of the course of treatment.

Analogues of the drug belonging to the group of tetracyclines: Doxycycline hydrochloride, Tygacil, Unidox, Tetracycline, Dovicin, Doxilan, Doksibene. From foreign analogues, doctors recommend using Vibramycin-D and Doxa-M.

When choosing an analogue, you should understand that all similar drugs will not give such a quick and effective action as the original, so it is much better to use Unidox Solutab.

Among consumers, there is an opinion that the drug Doxycycline and Unidox Solutab are complete analogues. This is a somewhat erroneous understanding, although these drugs contain one active substance - doxycycline, a broad-spectrum antibiotic.

The advantages of Unidox Solutab over the second drug is that the first one was created using modern technology, which allows the antibiotic to be absorbed into the blood faster, while the second drug is slower in action.

If patients take Doxycycline, and for a long time, it causes the destruction and yellowing of the tooth enamel.

It is not for nothing that manufacturers call the product “patient friendly”: all components go through several stages of purification, which makes it safe and does not cause side effects.

Drug interaction Unidox Solutab:

If the patient is taking medications that include iron, magnesium, calcium, aluminum, laxatives, Unidox Solutab is taken only after 3 hours.
Doses of indirect anticoagulants taken with this drug are subject to adjustment.
The drug reduces the effectiveness of bactericidal antibiotics taken, which also treat the disease.
The active substance of the drug, doxycycline, increases the risk of acyclic bleeding if you are taking hormonal contraceptives in parallel with the drug.
Simultaneous administration of the drug and retinol leads to an increase in intracranial pressure.

Unidox Solutab: how to take the drug for the treatment of prostatitis and other diseases

The drug is widely used in urology, in particular, for the treatment of prostatitis, since it contains one of the most effective substances - tetracycline.

Unidox Solutab, how to take with prostatitis:

The course of treatment can last from 2 to 3 weeks, but it all depends on the stage of development of the disease, what are your body characteristics and individual contraindications.

The doctor can change the daily dose of the drug.

Note that a child can also be treated with such an antibiotic, but only at the age of 8 years.

Food does not affect the intake of the drug in any way, therefore it is most often taken during meals (food helps the drug to be absorbed into the blood and plasma faster).

The daily dose of the drug is 2 tablets (1 in the morning and 1 in the evening).

The prefix to the main name of the drug "solutab" indicates that this remedy can be taken in different, convenient forms. Not all patients can take the drug whole or even chewed. For many, it is much easier to drink syrup or suspension. Therefore, the manufacturers have come up with such a reasonable solution as 1 tablet, which can be taken as usual or crushed into a powder and dissolved in water.

The advantage of this form of tablet is that the composition dissolved in water receives a higher biological activity, which means that it is absorbed faster in the gastrointestinal tract, gets into the blood, tissues of internal organs faster, where it acts on various kinds of infection.

Unidox Solutab, how to take it in the treatment of other pathologies:

For the treatment of uncomplicated gonorrhea, tablets are prescribed 2 times a day (100 mg each). The course of treatment lasts 1 week. The doctor may also recommend therapy in which you take 2 tablets for 1 day (300 mg at a time). Chlamydia is treated the same way.
primary syphilis. The course of treatment is 2 weeks. Taking tablets 2 times / day, 100 mg.
Secondary syphilis. The course of treatment is 28 days. Taking tablets daily, 2 times / day, 100 mg.
Uncomplicated urogenital infections. The course of treatment is 7 days. Taking tablets daily, 2 times / day, 100 mg.
Acne, endometritis. The course of treatment is from 6 to 12 weeks. Reception - 1 tablet (100 mg) / day. With acne, the drug affects every pimple that already has suppuration and inhibits the entire pathogenic environment.
Typhus is treated with a single dose of tablets. Depending on the severity of the disease, the administration is prescribed 100 mg or 200 mg of the drug at a time.
Prevention of traveler's diarrhea. On the first day of the trip, take 200 mg (for 1 or 2 times), then 100 mg / day. The course of admission can not be more than 3 weeks.
Malaria prophylaxis is carried out immediately before the trip, 1 or 2 days before the trip. During these days, 100 mg / day is taken. After returning home, the prophylactic course can last up to 4 weeks.
Prevention of abortion, to prevent the development of infectious diseases. Before the operation, 100 mg is administered for 1 hour and 200 mg immediately after the operation.
With streptococcus, the course of treatment is at least 10 days.

When a patient seeks treatment at a clinic, an examination and tests are carried out, according to the results of which, the doctor prescribes therapy with this antibiotic.

Such a wide range of diseases that can be treated with this remedy makes it popular among both doctors and patients.

An antibiotic of such a strong effect on the body is always taken on the recommendation of a doctor and strictly according to the regimen drawn up by him. Especially the dosage of Unidox Solutab should not be exceeded so as not to cause side effects.

Do not forget that this drug can be addictive and its effect on groups and strains of harmful microorganisms may be weakened.

The drug can be taken in two ways: taking a tablet with plenty of water, or you can dissolve 1 tablet in water (about 20 ml) and drink the resulting syrup, the taste of which is quite pleasant, which is why it is recommended for children to use tablets dissolved in water.

The drug is most effective when taken with food, but is not recommended immediately before bedtime.

The course of treatment, on average, with general and not severe infectious diseases, is from 5 to 10 days.

The maximum possible dose, which will not cause an overdose and the development of side effects, is from 300 mg / day or 600 mg of the drug for 5 days. This dose size is possible if the patient has a gonococcal infection.

For adults and children over 8 years of age and weighing over 50 kg is: on the first day 2 tablets (200 mg) in 1 or 2 doses. Subsequent days of therapy - 1 tablet (100 mg) / day.
For children aged 8 to 12 years, with a body weight of less than 50 kg, it is recommended to take 4 mg / day on the 1st day of therapy, and 2 mg / day per 1 kg of weight on subsequent days of treatment.
For the treatment of prostatitis, the doctor prescribes 1 tablet / day.
For the treatment of other diseases, the doctor develops an individual regimen for taking the drug. On average, the patient takes 1 to 2 tablets per day.
For the prevention of Unidox Solutab, 1 tablet is used for a short period. As a rule, the period of prophylaxis never exceeds 3 weeks.

This drug has some advantages over other antibiotics:

You can take medicine in the form of tablets, solution, syrup.
In the treatment of most infectious diseases, the drug is required only 1 time per day.
Even against the background of possible side effects, the drug never causes esophagitis, which very often occurs during tetracycline therapy.
The components of the drug can accumulate in the tissues, where they will actively fight against harmful microorganisms for a long period of time.

Such a broad-spectrum antibiotic also has special instructions for therapy.

Important to remember

Tetracyclines can affect the functions of the liver and kidneys, change the composition of the blood. Therefore, treatment should be carried out under the strict supervision of a physician.

After prolonged use of the drug, diarrhea may develop. In this case, to stabilize the state of the gastrointestinal tract, light, corrective agents are used - ion-exchange resins. In a severe situation, fluid replacement, the use of metronidazole or vancomycin is carried out.

During the period of therapy, drugs that can inhibit intestinal motility are not used.

According to recent studies, the drug very rarely causes side effects and is becoming more and more popular, both among patients and among doctors, who, with its help, can prescribe the most minimal courses of treatment for various infectious diseases, including their complex and severe forms.

Content

Being an antibiotic of the tetracycline series, Unidox Solutab, an instruction for use in ureaplasma, which allows the use of the drug in the treatment of infection, even for children from 8 years old, is considered an effective medicine. An antibiotic is taken strictly with a doctor's prescription, but since the disease is opportunistic, its treatment is not always appropriate. In what cases can you take a drug whose main active ingredient is doxycycline - this is detailed in the article.

What is ureaplasmosis

The disease is considered one of the most common sexually transmitted diseases. In addition, it has been recorded that there is a risk of infection by airborne droplets and from mother to fetus. At the present stage, the opinions of experts diverge dramatically, since there is no definite view of the disease, since the causative agents of ureaplasmosis are present in more than half of healthy women and a third of newborn girls. In men, it is extremely rare.

Pathogens are considered conditionally pathogenic, so the treatment of ureaplasma with an antibiotic, its expediency, is questionable, since there are several pathogenic types of ureaplasma that are not always relevant to treat:

parvum. A bacterium that breaks down urea, releasing ammonia. At excessive concentration, it can cause the formation of stones in various parts of the urinary system. They are the most dangerous.
urealiticum. It affects blood cells and sperm, and also has a detrimental effect on the mucous membrane.
spices. Inhabits numerous cells of the mucosa, can cause the development of infertility in men.

Composition

As already noted, the active substance that is part of Unidox is doxycycline. As auxiliary substances, the composition of the drug includes:

hypromellose;
giprolose (low-substituted);
colloidal (anhydrous) silicon dioxide;
lactose monohydrate;
magnesium stearate;
saccharin;
cellulose microcrystalline.

Is doxycycline effective for ureaplasma

The repeatedly proven effectiveness of Unidox in the treatment of ureaplasma allows the drug to be one of the main medicines in the treatment of the disease. To remove ureaplasma from the body, antibiotic treatment is considered the most progressive method. Particularly well proven preparations of the tetracycline group, so it can be argued that drug treatment gives its positive results.

How it works

The antibiotic, produced in the form of dispersible tablets engraved with "173", is active against the action of gram-negative and gram-positive microorganisms, since it is a broad-spectrum drug. However, the action of Unidox Solutab is selectively aimed at suppressing, among other things, ureaplasma by influencing the cellular structure of bacteria.

The drug not only inhibits the development of microorganisms, but also prevents their growth. Due to the fact that the absorption of the antibiotic occurs rapidly in the gastrointestinal tract, its penetration into many organs and tissues of the body, with the exception of the spinal cord, helps to increase the effectiveness of treatment at times. The indication for the use of Unidox Solutab exists even for people with diseased kidneys, since absorption occurs exclusively through the gastrointestinal tract.

The scheme of treatment of ureaplasma

In no case should you prescribe a drug for yourself, since only a specialist, after conducting various kinds of research, can talk about the possibility of prescribing Unidox from ureaplasma. Drug treatment consists not only in taking this antibiotic, but also in the inclusion of vaginal suppositories and douching in therapy. In addition, the doctor may prescribe Flucostat and Vilprafen - this scheme is considered more common and effective.

Unidox solutab - instructions for ureaplasma

According to the official instructions, the use of Unidox in ureaplasma is prescribed for a week, as for most antibiotics of the tetracycline group. You can order and buy the drug in the pharmacy network only by prescription, which is issued by the attending physician after the diagnosis. The shelf life of the antibiotic is 5 years, and it is required to store it in a dry place at a temperature not lower than 15 and not higher than 25 ° C.

While taking the drug, according to the instructions, alcohol is prohibited, since the concentration of Unidox Solutab in the blood decreases significantly. For this reason, treatment is considered ineffective. Women who are simultaneously treated with an antibiotic and take contraceptives should be aware that the effectiveness of contraceptives when taken together is reduced. In addition, menstruation may go outside the schedule. Another feature is that it reduces the bioavailability of antacids, so it is necessary to make an interval between taking these drugs.

How to drink Unidox

Before taking Unidox with ureaplasma, you should carefully read the prescriptions and follow all the advice of your doctor. Instructions for use of the antibiotic does not indicate a special connection of the drug with the main meals, but only limits the time interval between taking the medicine - it must be constant. According to reviews, it is still recommended to use Unidox Solutab with meals or immediately after a meal, drinking tablets with plenty of water.

Dosage

It is important to understand that the dosage of Unidox Solutab with ureaplasma depends entirely on the results of the study conducted before. The duration and doses of administration are prescribed purely individually, but, as a rule, the course of treatment lasts 7 days. If you turn to the instructions, then taking an antibiotic depends not only on the age of the patient, but also on his weight. If a person weighs more than 50 kg, on the first day it is necessary to take a double dose - 200 g, on the second and subsequent days, the treatment will be 100 g of the antibiotic once.

As can be seen from the title, and the word "solutab" to this direct evidence The tablets can be chewed or dissolved in water and taken as a syrup. This is not forbidden by the instruction, especially when it comes to children, who sometimes find it difficult to swallow a whole pill at a time. For children, the dosage is calculated from their weight, with 4 mg of the drug for each kilogram on the first day, and 2 mg on the following days.

How many days to drink Unidox Solutab with ureaplasma

Only a few antibiotics have the effect of accumulation in the body, which makes it possible to take them for no more than 3 days. The minimum duration of taking Unidox is a week. In some particularly severe cases, it can be increased, but all this happens only on the prescription of the attending physician, if the results of treatment are disappointing.

Side effects

Like most drugs, Unidox has side effects. The most common include vomiting and nausea, diarrhea, and abdominal pain. Some patients may experience inflammation of the pancreas and colon. Erosion of the esophagus is not excluded, therefore it is recommended to take the antibiotic strictly in a standing position. When taking tests, there may be a violation of the microflora of the vagina and intestines and fungal infections can be noted.

Unidox price

It is noteworthy that the antibiotic, compared with other similar drugs - and there are a considerable number of them - has an acceptable cost, which makes it indispensable in treatment from a financial point of view. When selling the drug in online pharmacies in Moscow and St. Petersburg, an additional fee may be charged for the delivery of the order to the specified address. Further in the table, you can see approximately how much tablets cost in a package of 10 pieces in the capital region.

Unidox Solutab instructions for use are positioned as an effective antibacterial agent of the tetracycline series. The original remedy patented by the Dutch pharmaceutical company Astella Pharma Europe (Astellas Pharma Europe) is Unidox Solutab, which is another “pharma reincarnation” of Doxycycline, known since the last century. The price of Unidox is not the lowest. Budget antibiotic can hardly be called. The cost of the drug starts from 345 rubles

The drug (PM) affects a wide group of infectious agents: coccal flora, Yersinia, Listeria, Clostridia, Haemophilus influenzae, Yersinia. Suppresses the growth of a large list of bacteria that cause STDs and some protozoa (myco- and ureaplasma, Neisseria, chlamydia).

An agent that suppresses protein synthesis in a microbial cell, this is how Unidox Solutab describes the instructions for use. This happens due to interaction with the ribosomal subunit (30S). This leads to a slowdown in the growth of pathogens.

General characteristics of the drug

Despite the wide possibilities, the drug is not universal. The instruction enclosed in the box with the Unidox Solutab preparation warns that in the event of the development of a proteus, enterococcal infection, infection with pseudomonads, providence and serration, treatment with this antibiotic will not be effective.

Another potential disadvantage of the drug is the possibility of acquiring cross-resistance by microorganisms. This means that strains that are not sensitive to the described drug will be indifferent to other tetracyclines. With resistance to any drug in this group, it is pointless to try Unidox treatment.

The advantages of the tool include:

Rapid absorption in the digestive system.
The excellent ability of the active component of the agent to penetrate tissues in a matter of minutes (after 30-45 minutes it can be found in all target organs, as well as body fluids, except for cerebrospinal fluid).
Food does not significantly affect the absorption of the drug. This is convenient for the patient. It is easier to drink drugs during a meal than to count 60 minutes after a meal.
Instructions Unidox recommends for a variety of diseases with different etiologies and clinical specifics from ENT pathology and "invasion" of the skin to damage to the genitals by bacteria and some protozoa.

The effectiveness of the drug is ensured by a competent therapeutic regimen selected by a doctor. The medicine is not intended for self-medication.

Release form

The drug cannot boast of a wealth of options, but it is quite comfortable with the convenience of a single form. The antibiotic Solutab Unidox is produced as an aqueous soluble (dispersible) tablet.

Each water-soluble pill is colored yellowish, convex on both sides, with a notch and digital engraving "on the back" - 173.

Tablets are round, medium-sized. Packed in cellular packaging and cardboard. Their active element is doxycycline in the amount of 0.1 grams. There are also a number of auxiliary components, including saccharin and lactose.

Contraindications and side effects

Instruction Solutab Unidox categorically does not recommend prescribing:

Children under 8 years of age, to avoid the formation of insoluble compounds with calcium in bone structures.
Pregnant and lactating women.
If you are intolerant or allergic to any of the tetracyclines or an additional ingredient of the product.
Porfiria.
In the case of diagnosed severe pathologies of the "filtration system" of the body (liver and kidneys).
With leukopenia.

The antibiotic Unidox Solutab can cause a negative reaction from almost all major systems of the human body. Most often it is the immune system (allergy, anaphylaxis, photosensitization), gastrointestinal tract (nausea, complete lack of appetite, vomiting, esophagitis, enterocolitis, diarrhea) and generalized or localized mucosal candidiasis (stomatitis, glossitis, vaginitis, proctitis).

In patients who are forced to take the drug for a long time, there is a browning of the glandular tissues of the "thyroid gland". Changes are reversible. There is a reaction of the central nervous system in the form of benign ICP. The blood system is also "not indifferent" to the drug and may react with anemia, thrombocytopenia and a decrease in prothrombin activity.

The hepatotoxic effect was observed only in persons with a diseased liver and / or kidneys. With frequent or prolonged use, the amount of nitrogen in the urine may increase. When taking the medicine by children, the color of the enamel may be irreversibly attracted, its dysplasia develops.

The standard rules for using the medicine are as follows - Solutab Unidox is drunk with food:

swallowing and curling with a small (up to 20 ml) volume of water;
chewing;
dividing into several parts;
grinding in any convenient way;
dissolving in a small (up to 20 ml) volume of water.

The standard therapeutic course is from 5 to 10 days. The dosage depends on the age and body weight of the patient:

Patients with a weight of 50 kg and over 8 years of age are recommended to take the medicine according to the scheme: 1st day - 2 tablets or 0.2 g / 1-2 doses, from the 2nd day 1 tablet or 0.1 g / day . In case of severe infection, it is permissible to increase the dose to 0.2 g / day during the course.
For children 8-12 years old, whose body weight has not reached 50 kg, it is recommended to take: 1st day 4 mg / kg / day, from 2 days 2 mg / kg / day (for one or 2 doses). In extremely severe cases, you can increase the daily dose to 4 mg / kg / day.

Acceptance for various indications

In urogenital infections, the treatment regimen may vary depending on the severity of the pathology and the presence of complications. Treatment of ureaplasma urealiticum (more precisely, the diseases caused by it) requires a 7-day course of therapy, 1 tablet twice a day. Unidox Solutab instructions for use in ureaplasma recommends taking in case of development of uncomplicated cervicitis, urethritis. The drug is effective in the indicated dose and with chlamydial infection.

Uncomplicated gonorrhea is also amenable to doxycycline, except for anorectal lesions in men. Adults are recommended to use one of 2 schemes:

1 tablet 2 times a day - 7 days (or until complete cure).
Double dose of 3 tablets per dose with an interval of 1 hour (total dose will be 600 mg). This is the maximum dose that an adult can take per day.

If the cost of Unidox Solutab 100 mg suits the patient, this remedy is suitable for combating acne. The question of price arises because a rather long-term (6-12 weeks) use of the drug at a dose of 0.1 g / day is required.

In case of medical termination of pregnancy (abortion), the medicine is taken in a short course: the 1st dose before the intervention is 1 tablet, the 2nd dose after the procedure is 2 tablets.

The described drug or a qualitative analogue of Unidox Solutab should be in the first aid kit for every traveler. It is prescribed for the prevention of malaria, as well as for traveler's diarrhea. In the latter case, the medicine should not be taken for more than 21 days.

If you are going to places with unfavorable epidemiological status, take 2 tablets of the remedy on the day of departure, and then drink 1 tablet every day.

treatment - 0.1 g / dose - twice a day, a course of a week;
prevention - 0.2 g / dose once a week.

The last 2 tablets are needed upon returning from a dysfunctional region. Having dealt with the recommendations that the instructions for use give for Unidox Solutab, the price of the drug can also be considered “under the microscope”.

The cost of the drug

Why does the price depend on Unidox Solutab if the drug is released in the form of dispersible tablets and is not presented as a syrup, suppositories or in any other form? Mostly from the pharmacy chain where you plan to buy the product and from the region of residence.

The dispersibility of tablets is the main difference from similar drugs, which gives instructions for Unidox Solutab, while the price for it can be an order of magnitude higher than incomplete analogues. For Solutab, the price ranges from 266 to 400 rubles.

Unidox Solutab - official instructions for use

Similar drugs

Are there any drugs for the described drug that can replace it. Of course, such medicines exist. Moreover, they are not all available in tablet form. It can be capsules, less often - lyophilisate. The main analogues for drugs Unidox Solutab are drugs with the same active ingredient in the composition: Xedocin, Doxidar 100, Doxycycline in the form of hydrochloride (capsules), Vibramycil, Vidoccin (lyophilisate), Doxal; Bassada, Monoklin and others.

For patients who are not satisfied with the price of Unidox Solutab, we will report analogues cheaper. The cheapest is Doxycycline hydrochloride (capsules). The drug costs from 17 to 30 rubles for 10 tablets.

Considering that there are analogues for the drug Solutab Unidox that are much more attractive in price, why is the medicine in demand? Let's look for the answer in the reviews.

Summary of Reviews

The main advantage that patients note when using the described medication is its minimal irritating activity on the gastrointestinal mucosa. Those patients who could not take analogues of this medication leave Unidox Solutab reviews with a big plus precisely because of this quality. In terms of effectiveness, the drug is at a level with similar drugs.

If we consider the use of Unidox Solutab for acne, the reviews for this remedy are positive if the sensitivity of the pathogen to tetracycline is determined, the treatment regimen is correctly prescribed and scrupulously maintained.

Information about the drug is distributed for informational purposes only. Do not self-medicate, consult a doctor for prescriptions!

The drug Unidox Solutab contains active ingredient doxycycline- an antibiotic of the tetracycline group. Doxycycline has a bacteriostatic effect due to the inhibition of the synthesis and metabolism of proteins contained in the cell membrane of microorganisms. In addition, the drug disrupts the connection of certain types of RNA with the ribosome membrane. The drug is characterized by a significantly higher activity against cultures of microorganisms that are in the functional stage of growth and division, at the same time, the drug has practically no effect on microorganisms in the dormant stage.

The bacteriostatic effect of the drug extends to a wide range of microorganisms, including:
Gram-positive bacteria: Streptococcus haemolyticus, Streptococcus pneumoniae, Streptococcus viridans, Streptococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Listeria spp., including Listeria monocytogenes.
Gram-negative bacteria: Bacillus anthracis, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influence, Brucella spp., Clostridium spp., Escherichia coli, Shigella spp., Salmonella spp., Yersinia spp., Vibrio spp., Pasteurella spp., Propionibacterium acnes, Enterobacter spp., Klebsiella spp., Bacteroides spp., Entamoeba histolytica.
Bacteria that cause sexually transmitted infections (STIs): Mycoplasma spp., Chlamydia spp., Rickettsia spp., Spirochaeta spp.
The drug is inactive against Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

A drug Unidox Solutab well absorbed from the gastrointestinal tract when taken orally, food intake practically does not change the degree of absorption of doxycycline. The maximum concentration of the drug in the blood plasma is reached within 2 hours after oral administration of the drug. About 90% of doxycycline is reversibly bound to plasma proteins, the drug penetrates well into tissues, but is practically not detected in the cerebrospinal fluid. The drug is partially metabolized in the body with the formation of active and inactive metabolites. The active metabolites of the drug and doxycycline unchanged are excreted mainly in the urine, inactive metabolites (mainly chelated compounds) are excreted in the feces. The half-life with a single use is 16-18 hours, with repeated administration of the drug, the half-life increases and is about 22-23 hours. In patients with renal insufficiency, the half-life does not change.

The drug is found in high concentrations in the tissues of the prostate gland. Doxycycline crosses the hematoplacental barrier, some doxycycline is excreted in breast milk.

Indications for use

Unidox Solutab is used to treat infectious diseases caused by doxycycline-susceptible microorganisms in adults and children over 8 years of age, including:
- infectious diseases of the upper respiratory tract and respiratory tract;
- infectious diseases of the gastrointestinal tract;
- infectious diseases of the genitourinary system, including gonorrhea, chlamydial infections, urogenital mycoplasmosis, primary and secondary syphilis, pyelonephritis, cystitis, prostatitis;
- infections of soft tissues and skin, including acne;
- typhus.

Mode of application

Doses of the drug and the duration of the course of treatment are determined by the attending physician individually for each patient.

Usually, adults and children weighing more than 50 kg are prescribed on the first day of treatment 200 mg of the drug 1 time per day or 100 mg of the drug 2 times a day. Starting from the second for therapy, the drug is taken in a daily dose of 100 mg.
In severe infectious diseases, 200 mg of the drug is prescribed daily during the entire course of therapy.

Children over 8 years of age weighing less than 50 kg are prescribed at the rate of 4 mg/kg of body weight on the first day of treatment and 2 mg/kg of body weight per day during the entire course of drug treatment. In severe infectious conditions, 4 mg / kg body weight is prescribed 1 time per day during the entire course of therapy.

For the treatment of gonorrhea, women are prescribed 200 mg of the drug daily, the course of treatment is at least 5 days. Men are prescribed 200-300 mg for 2-4 days. Or 300 mg 2 times a day (break between taking tablets 1 hour), the course dose for this treatment regimen is 600 mg.
For the treatment of primary and secondary syphilis, usually 300 mg per day is prescribed. The course of treatment is at least 10 days.
For the treatment of typhus, the drug is taken once at a dose of 100-200 mg.

Tablets Unidox Solutab taken orally as a whole, the tablet can also be divided or crushed, washed down with the drug with the required amount of water. The crushed tablet can also be diluted with water to form a syrup (approximately 20 ml of water) or suspension (up to 100 ml of water).
The dose of the drug is recommended to be taken at a time, unless otherwise prescribed.

Side effects

When using the drug in patients, the following side effects were noted:
From the gastrointestinal tract: nausea, vomiting, loss of appetite, dysphagia, glossitis, stool disorders, enterocolitis.
On the part of the hematopoietic system: hemolytic anemia, thrombocytopenia, eosinophilia, a decrease in the prothrombin index.
From the side of the central nervous system: dizziness, headache, increased intracranial pressure.
From the skin: erythema, dermatitis, photosensitivity.
Allergic reactions: pruritus, rash, urticaria, Quincke's edema, anaphylactic reactions. Perhaps the development of pericarditis and exacerbation of systemic lupus erythematosus.
Other side effects: the development of candidal infections, including vaginitis, glossitis, stomatitis.

Contraindications

- Increased individual sensitivity to the components of the drug and tetracyclines;
- acute and chronic renal and / or liver failure;
- period of pregnancy and lactation;
- children's age up to 8 years.

Pregnancy

The drug is contraindicated for use during pregnancy, since doxycycline can cause impaired bone formation in the fetus.
If it is necessary to use the drug during lactation, it is necessary to resolve the issue of stopping breastfeeding.

Interaction with other drugs

The drug is not prescribed simultaneously with penicillin antibiotics, cephalosporins and other antimicrobial drugs that have a bactericidal effect.
Due to the chemical reaction of doxycycline with metals and antacids, inactive compounds are formed, so the simultaneous administration of these drugs is undesirable.
With the simultaneous use of the drug with anticoagulants, it is necessary to take into account the possibility of changing the prothrombin time.

Overdose

In case of overdose, patients experience nausea, vomiting, dizziness, diarrhea, anorexia, headache.
There is no specific antidote. Shown gastric lavage, intake of enterosorbents, symptomatic treatment.